Evidence map›Paper›PMID 25853140›Full record

ArticleBioMed research international2015

Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.

B A Mysona, S Matragoon, M Stephens, I N Mohamed, A Farooq, M L Bartasis, A Y Fouda, A Y Shanab, D G Espinosa-Heidmann, A B El-Remessy

Open access · hybridAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Deletion of p75Scientific reports · 2018
    Article
  15. Article
  16. Article
  17. Implication of the neurotrophin receptor p75Expert review of ophthalmology · 2017
    Article
  18. Deletion of the Neurotrophin Receptor p75Journal of diabetes, metabolic disorders & control · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

B A MysonaProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
S MatragoonProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
M StephensCulver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA.
I N MohamedProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
A FarooqProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
M L BartasisProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
A Y FoudaProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
A Y ShanabProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
D G Espinosa-HeidmannCulver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA.
A B El-RemessyProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
Augusta University · USDiscovery Institute · USCharlie Norwood VA Medical Center · USUniversity of Georgia · US

Funding

Molecular Mechanisms of diabetic retinopathyR01EY022408 · NEI · UNIVERSITY OF GEORGIA · PI EL-REMESSY, AZZA B · 2012 to 2016
$1.5M
NEI NIH HHS EY-0022408NEI NIH HHS R01 EY022408
6 · The paper itself

Abstract

Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. This imbalance coincided with retinal damage in experimental diabetes. Here we test the hypothesis that alteration of proNGF and NGF levels observed in retina and vitreous will be mirrored in serum of diabetic patients. Blood and vitreous samples were collected from patients (diabetic and nondiabetic) undergoing vitrectomy at Georgia Regents University under approved IRB. Levels of proNGF, NGF, and p75(NTR) shedding were detected using Western blot analysis. MMP-7 activity was also assayed. Diabetes-induced proNGF expression and impaired NGF expression were observed in vitreous and serum. Vitreous and sera from diabetic patients (n = 11) showed significant 40.8-fold and 3.6-fold increases, respectively, compared to nondiabetics (n = 9). In contrast, vitreous and sera from diabetic patients showed significant 44% and 64% reductions in NGF levels, respectively, compared to nondiabetics. ProNGF to NGF ratios showed significant correlation between vitreous and serum. Further characterization of diabetes-induced imbalance in the proNGF to NGF ratio will facilitate its utility as an early biomarker for diabetic complications.

Indexed as

AdolescentAdultAgedAnimalsBiomarkersCase-Control StudiesDiabetes ComplicationsDiabetes Mellitus, ExperimentalDiabetic RetinopathyFemaleGeorgiaHumansMaleMiddle AgedNerve Growth FactorPilot ProjectsBiomarkersNerve Growth FactorNGF protein, humanProtein Precursors

Identifiers

PMID25853140
PMCPMC4380101
OpenAlexW1986121436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.