Evidence map›Paper›PMID 25853123›Full record

ArticleFrontiers in chemistry2015

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents.

Athina Dimopoulou, Stella Manta, Vanessa Parmenopoulou, Nikolaos Kollatos, Ourania Christidou, Virginia V Triantakonstanti, Dominique Schols, Dimitri Komiotis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Synthesis and anticancer activity of multisubstituted purines and xanthines with one or two propynylthio and aminobutynylthio groups.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Athina DimopoulouLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
Stella MantaLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
Vanessa ParmenopoulouLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
Nikolaos KollatosLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
Ourania ChristidouLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
Virginia V TriantakonstantiLaboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki Thessaloniki, Greece.
Dominique ScholsDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven Leuven, Belgium.
Dimitri KomiotisLaboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
University of Thessaly · GRRega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells.

Indexed as

8-bromoadeninecytotoxic activitymicrowave irradiationN6-benzoyladenine pyranonucleosidesSonogashira coupling reaction

Identifiers

PMID25853123
PMCPMC4369668
OpenAlexW2031385899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.