ReviewQuantitative imaging in medicine and surgery2015
White matter in temporal lobe epilepsy: clinico-pathological correlates of water diffusion abnormalities.
Review in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 72 citations in OpenAlex.
- CA1 parvalbumin interneurons display alterations of myelin patterning driven by microgliosis in temporal lobe epilepsy.Scientific reports · 2026Article
- Altered white matter structural network in self-limited epilepsy with centrotemporal spikes.Quantitative imaging in medicine and surgery · 2026Article
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- Synergistic Effect between theInternational journal of molecular sciences · 2024Article
- Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging.Brain and behavior · 2023Article
- A DEEP LEARNING FRAMEWORK TO LOCALIZE THE EPILEPTOGENIC ZONE FROM DYNAMIC FUNCTIONAL CONNECTIVITY USING A COMBINED GRAPH CONVOLUTIONAL AND TRANSFORMER NETWORK.Proceedings. IEEE International Symposium on Biomedical Imaging · 2023Article
- DeepEZ: A Graph Convolutional Network for Automated Epileptogenic Zone Localization From Resting-State fMRI Connectivity.IEEE transactions on bio-medical engineering · 2023Article
- Differentiation of Epileptic Brain Abnormalities among Neurological Patients at Taif Region Using MRI.International journal of clinical practice · 2023Article
- Adaptive and maladaptive myelination in health and disease.Nature reviews. Neurology · 2022Review
- Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats.Molecular biology reports · 2022Article
- High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy.NeuroImage · 2022Article
- Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice.Journal of lipid research · 2022Article
- Brain tissue integrity mapping in adults with obstructive sleep apnea using T1-weighted and T2-weighted images.Therapeutic advances in neurological disorders · 2022Article
- Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI.Neuroradiology · 2022Article
- The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models.International journal of molecular sciences · 2021Review
- Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx).Brain imaging and behavior · 2021Article
- Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies.Neuropathology and applied neurobiology · 2021Article
- Fiber ball white matter modeling in focal epilepsy.Human brain mapping · 2021Article
- Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy.Frontiers in neurology · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
Using magnetic resonance imaging, it is possible to measure the behavior of diffusing water molecules, and the metrics derived can be used as indirect markers of tissue micro-architectural properties. Numerous reports have demonstrated that patients with temporal lobe epilepsy (TLE) have water diffusion abnormalities in several white matter structures located within and beyond the epileptogenic temporal lobe, showing that TLE is not a focal disorder, but rather a brain network disease. Differences in severity and spatial extent between patients with or without mesial temporal sclerosis (MTS), as well as differences related to hemispheric seizure onset, are suggestive of different pathophysiological mechanisms behind different forms of TLE, which in turn result in specific cognitive disabilities. The biological interpretation of diffusion abnormalities is based on a wealth of information from animal models of white matter damage, and is supported by recent reports that directly correlate diffusion metrics with histological characteristics of surgical specimens of TLE patients. Thus, there is now more evidence showing that the increased mean diffusivity (MD) and concomitant reductions of diffusion anisotropy that are frequently observed in several white matter bundles in TLE patients reflect reduced axonal density (increased extra-axonal space) due to smaller-caliber axons, and abnormalities in the myelin sheaths of the remaining axons. Whether these histological and diffusion features are a predisposing factor for epilepsy or secondary to seizures is still uncertain; some reports suggest the latter. This article summarizes recent findings in this field and provides a synopsis of the histological features seen most frequently in post-surgical specimens of TLE patients in an effort to aid the interpretation of white matter diffusion abnormalities.
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