ReviewQuantitative imaging in medicine and surgery2015
The effects of antiepileptic drugs on cognitive functional magnetic resonance imaging.
Review in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Is a Responsive Default Mode Network Required for Successful Working Memory Task Performance?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- A cross-sectional and longitudinal study of changes in complex networks related to brain function in temporal lobe epilepsy patients treated with levetiracetam intervention therapy.Brain imaging and behavior · 2026Article
- Neurobehavioral therapy in functional seizures: Investigation of mechanism of action with resting-state functional magnetic resonance imaging.Epilepsia · 2025Article
- Brain functional connectivity and activity during motor control in children with cerebral palsy: a pilot cross-sectional fNIRS study.Translational pediatrics · 2025Article
- Optimized microburst VNS elicits fMRI responses beyond thalamic-specific response from standard VNS.Annals of clinical and translational neurology · 2024Article
- Increased interictal synchronicity of respiratory related brain pulsations in epilepsy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.Inflammopharmacology · 2020Article
- Understanding the Cognitive Side Effects of Antiepileptic Drugs: Can Functional Imaging Be Helpful?Epilepsy currents · 2019Article
- Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy.Frontiers in neurology · 2019Review
- Longitudinal Effects of Bumetanide on Neuro-Cognitive Functioning in Drug-Resistant Epilepsy.Frontiers in neurology · 2019Article
- Reconfiguration of Intrinsic Functional Coupling Patterns Following Circumscribed Network Lesions.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy.Human brain mapping · 2017Article
- Pharmaco fMRI: Determining the functional anatomy of the effects of medication.NeuroImage. Clinical · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cognitive dysfunction caused by antiepileptic drugs (AEDs) has been extensively described, although the mechanisms underlying such collateral effects are still poorly understood. The combination of functional magnetic resonance imaging (fMRI) studies with pharmacological intervention (pharmaco-MRI or ph-MRI) offers the opportunity to investigate the effect of drugs such as AEDs on brain activity, including cognitive tasks. Here we review the studies that investigated the effects of AEDs [topiramate (TPM), lamotrigine (LMT), carbamazepine (CBZ), pregabalin (PGB), valproate (VPA) and levetiracetam (LEV)] on cognitive fMRI tasks. Despite the scarcity of fMRI studies focusing on the impact of AEDs on cognitive task, the results of recent work have provided important information about specific drug-related changes of brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.