ArticleJournal of oral biology and craniofacial research
Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Interventions for managing oral submucous fibrosis.The Cochrane database of systematic reviews · 2024Pooled it
- Clinical Assessment of Efficacy of Omega 3 in Oral Submucous Fibrosis Patients - A Randomized Controlled Trial.Asian Pacific journal of cancer prevention : APJCP · 2022Trial
- Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study.Asian Pacific journal of cancer prevention : APJCP · 2021Trial
- Protective effect of Spirulina andOpen veterinary journal · 2025Article
- Dynamic characterization of vascular response and treatment in oral traumatic ulcer in mice via photoacoustic imaging.Quantitative imaging in medicine and surgery · 2024Article
- Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts: an in silico and in vitro analysis.Molecular biology reports · 2024Article
- Drug treatment for oral submucous fibrosis: an update.BMC oral health · 2023Review
- Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Application ofLife (Basel, Switzerland) · 2023Review
- In Silico Analysis and Comparative Molecular Docking Study of FDA Approved Drugs with Transforming Growth Factor Beta Receptors in Oral Submucous Fibrosis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Comparative Efficacy of Interventions for the Management of Oral Submucous Fibrosis: A Systematic Review and Network Meta-Analysis.Journal of personalized medicine · 2022Review
- A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis.Antioxidants (Basel, Switzerland) · 2022Review
- Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Review
- Clinical Effectiveness of Aloe Vera in the Management of Oral Mucosal Diseases- A Systematic Review.Journal of clinical and diagnostic research : JCDR · 2016Review
- Evaluation of Efficacy of Curcumin along with Lycopene and Piperine in the Management of Oral Submucous Fibrosis.Contemporary clinical dentistryArticle
- Comparative evaluation of spirulina and lycopene as an adjuvant to intralesional corticosteroid injection therapy in the management of oral submucous fibrosis: A pilot study.National journal of maxillofacial surgeryArticle
- Medicinal management of oral submucous fibrosis in the past decade- A systematic review.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF. MATERIAL AND
methods42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.
resultsThe patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.
conclusionBoth the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
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