ArticleEJNMMI research2015
Transcriptional response in normal mouse tissues after i.v. (211)At administration - response related to absorbed dose, dose rate, and time.
Article in EJNMMI research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 63 citations in OpenAlex.
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- Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment.Scientific reports · 2022Article
- The IRI-DICE hypothesis: ionizing radiation-induced DSBs may have a functional role for non-deterministic responses at low doses.Radiation and environmental biophysics · 2020Article
- Preclinical Evaluation of Radiation-Induced Toxicity in Targeted Alpha Therapy Using [Translational oncology · 2020Article
- Transcriptional effects ofEJNMMI research · 2019Article
- Radiation-Induced Gene Expression Changes in High and Low Grade Breast Cancer Cell Types.International journal of molecular sciences · 2018Article
- Deconvolution of expression microarray data reveals 131I-induced responses otherwise undetected in thyroid tissue.PloS one · 2018Article
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- Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy.Cancer nanotechnology · 2016Review
- Gene expression signature in mouse thyroid tissue after (131)I and (211)At exposure.EJNMMI research · 2015Article
- Circadian rhythm influences genome-wide transcriptional responses to (131)I in a tissue-specific manner in mice.EJNMMI research · 2015Article
- Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.PloS one · 2015Article
- Inverse dose protraction effects of high-LET radiation: Evidence and significance.Mutation research. Reviews in mutation researchReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-critical levels. However, few studies have investigated normal tissue responses in vivo after (211)At administration. In order to identify molecular biomarkers of ionizing radiation exposure, we investigated genome-wide transcriptional responses to (very) low mean absorbed doses from (211)At in normal mouse tissues.
methodsFemale BALB/c nude mice were intravenously injected with 1.7 kBq (211)At and killed after 1 h, 6 h, or 7 days or injected with 105 or 7.5 kBq and killed after 1 and 6 h, respectively. Controls were mock-treated. Total RNA was extracted from tissue samples of kidney cortex and medulla, liver, lungs, and spleen and subjected to microarray analysis. Enriched biological processes were categorized after cellular function based on Gene Ontology terms.
resultsResponses were tissue-specific with regard to the number of significantly regulated transcripts and associated cellular function. Dose rate effects on transcript regulation were observed with both direct and inverse trends. In several tissues, Angptl4, Per1 and Per2, and Tsc22d3 showed consistent transcript regulation at all exposure conditions.
conclusionsThis study demonstrated tissue-specific transcriptional responses and distinct dose rate effects after (211)At administration. Transcript regulation of individual genes, as well as cellular responses inferred from enriched transcript data, may serve as biomarkers in vivo. These findings expand the knowledge base on normal tissue responses and may help to evaluate and limit side effects of radionuclide therapy.
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