ArticleAnnals of intensive care2015
Failed noninvasive positive-pressure ventilation is associated with an increased risk of intubation-related complications.
Article in Annals of intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 97 citations in OpenAlex.
- Early prediction of noninvasive ventilation failure after extubation: development and validation of a machine-learning model.BMC pulmonary medicine · 2022Trial
- Noninvasive ventilation versus conventional oxygen therapy after extubation failure in high-risk patients in an intensive care unit: a pragmatic clinical trial.Revista Brasileira de terapia intensiva · 2021Trial
- Integrating validated scores with clinical parameters to predict NIV weaning outcomes: a prospective study in the respiratory ICU.Scientific reports · 2026Observational
- Construction of a nomogram prediction model for prolonged ICU length of stay in patients with sepsis-induced coagulopathy.European journal of medical research · 2026Article
- The Prognostic Value of PaCOInternational journal of chronic obstructive pulmonary disease · 2026Article
- Effect of early intubation on patient-centered outcomes in urosepsis: a retrospective multicenter cohort study.Journal of intensive care · 2025Article
- Non-Invasive Positive Pressure Ventilation for Pre-Oxygenation of Critically Ill Patients Before Intubation.Journal of clinical medicine · 2025Review
- A Multicenter Retrospective Study Predicting Early Noninvasive Ventilation Failure in Patients With Acute Hypoxic Respiratory Failure.The clinical respiratory journal · 2025Article
- Prevalence, risk factors and consequences of early clinical deterioration under non-invasive ventilation in emergency department patients: a prospective, multicentre, observational study of the French IRU Network.Critical care (London, England) · 2025Observational
- Impact of initial ventilation strategies on in-hospital mortality in sepsis patients: insights from the MIMIC-IV database.BMC pulmonary medicine · 2025Article
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- Non-Invasive Ventilation for Community-Acquired Pneumonia: Outcomes and Predictors of Failure from an ICU Cohort.Medicina (Kaunas, Lithuania) · 2023Observational
- Associations With Severe Desaturation Events Among Children Receiving Noninvasive Respiratory Support at Time of Intubation.Respiratory care · 2023Article
- High-value care for critically ill oncohematological patients: what do we know thus far?Critical care science · 2023Review
- Article
- SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.Internal and emergency medicine · 2022Article
- Non-invasive ventilation for acute hypoxaemic respiratory failure: a propensity-matched cohort study.BMJ open respiratory research · 2022Article
- Accuracy evaluation of mainstream and sidestream end-tidal carbon dioxide monitoring during noninvasive ventilation: a randomized crossover trial (MASCAT-NIV trial).Journal of intensive care · 2022Article
- Factors and Outcomes Associated with Failed Noninvasive Positive Pressure Ventilation in Patients with Acute Respiratory Failure.International journal of general medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNoninvasive positive-pressure ventilation (NIPPV) use has increased in the treatment of patients with respiratory failure. However, despite decreasing the need for intubation in some patients, there are no data regarding the risk of intubation-related complications associated with delayed intubation in adult patients who fail NIPPV. The objective of this study is to evaluate the odds of a composite complication of intubation following failed NIPPV compared to patients intubated primarily in the medical intensive care unit (ICU).
methodsThis is a single-center retrospective cohort study of 235 patients intubated between 1 January 2012 and 30 June 2013 in a medical ICU of a university medical center. A total of 125 patients were intubated after failing NIPPV, 110 patients were intubated without a trial of NIPPV. Intubation-related data were collected prospectively through a continuous quality improvement (CQI) program and retrospectively extracted from the medical record on all patients intubated on the medical ICU. A propensity adjustment for the factors expected to affect the decision to initially use NIPPV was used, and the adjusted multivariate regression analysis was performed to evaluate the odds of a composite complication (desaturation, hypotension, or aspiration) with intubation following failed NIPPV versus primary intubation.
resultsA propensity-adjusted multivariate regression analysis revealed that the odds of a composite complication of intubation in patients who fail NIPPV was 2.20 (CI 1.14 to 4.25), when corrected for the presence of pneumonia or acute respiratory distress syndrome (ARDS), and adjusted for factors known to increase complications of intubation (total attempts and operator experience). When a composite complication occurred, the unadjusted odds of death in the ICU were 1.79 (95% CI 1.03 to 3.12).
conclusionsAfter controlling for potential confounders, this propensity-adjusted analysis demonstrates an increased odds of a composite complication with intubation following failed NIPPV. Further, the presence of a composite complication during intubation is associated with an increased odds of death in the ICU.
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