ArticleFrontiers in microbiology2015
rpoN1, but not rpoN2, is required for twitching motility, natural competence, growth on nitrate, and virulence of Ralstonia solanacearum.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 42 citations in OpenAlex.
- Twitching Motility Dynamics in the Wilt-Causing Phytopathogen Ralstonia solanacearum.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Transcriptome profiling of type VI secretion system core geneMicrobiology spectrum · 2024Article
- Transcriptomic analysis of Ralstonia solanacearum in response to antibacterial volatiles of Bacillus velezensis FZB42.Archives of microbiology · 2023Article
- CombinedACS omega · 2023Article
- Plant-PathogenicmBio · 2023Article
- The Regulatory Functions of σInternational journal of molecular sciences · 2021Review
- Light modulates important physiological features of Ralstonia pseudosolanacearum during the colonization of tomato plants.Scientific reports · 2021Article
- Transcriptome Analysis Revealed Overlapping and Special Regulatory Roles of RpoN1 and RpoN2 in Motility, Virulence, and Growth ofFrontiers in microbiology · 2021Article
- RpoN1 and RpoN2 play different regulatory roles in virulence traits, flagellar biosynthesis, and basal metabolism in Xanthomonas campestris.Molecular plant pathology · 2020Article
- Review
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- Role of RpoN fromApplied and environmental microbiology · 2019Article
- Response regulator VemR regulates the transcription of flagellar rod gene flgG by interacting with σMolecular plant pathology · 2019Article
- A practical random mutagenesis system for Ralstonia solanacearum strains causing bacterial wilt of Pogostemon cablin using Tn5 transposon.World journal of microbiology & biotechnology · 2018Article
- Root mediated uptake of Salmonella is different from phyto-pathogen and associated with the colonization of edible organs.BMC plant biology · 2018Article
- A Short Protocol for Gene Knockout and Complementation in Xylella fastidiosa Shows that One of the Type IV Pilin Paralogs (PD1926) Is Needed for Twitching while Another (PD1924) Affects Pilus Number and Location.Applied and environmental microbiology · 2018Article
- Involvement of ralfuranones in the quorum sensing signalling pathway and virulence of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2018Article
- Systematic Functional Analysis of Sigma (σ) Factors in the PhytopathogenFrontiers in microbiology · 2018Article
- RpoN (σApplied and environmental microbiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant pathogen Ralstonia solanacearum has two genes encoding for the sigma factor σ(54): rpoN1, located in the chromosome and rpoN2, located in a distinct "megaplasmid" replicon. In this study, individual mutants as well as a double mutant of rpoN were created in R. solanacearum strain GMI1000 in order to determine the extent of functional overlap between these two genes. By virulence assay we observed that rpoN1 is required for virulence whereas rpoN2 is not. In addition rpoN1 controls other important functions such twitching motility, natural transformation and growth on nitrate, unlike rpoN2. The rpoN1 and rpoN2 genes have different expression pattern, the expression of rpoN1 being constitutive whereas rpoN2 expression is induced in minimal medium and in the presence of plant cells. Moreover, the expression of rpoN2 is dependent upon rpoN1. Our work therefore reveals that the two rpoN genes are not functionally redundant in R. solanacearum. A list of potential σ(54) targets was identified in the R. solanacearum genome and suggests that multiple traits are under the control of these regulators. Based on these findings, we provide a model describing the functional connection between RpoN1 and the PehR pathogenicity regulator and their dual role in the control of several R. solanacearum virulence determinants.
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