Evidence map›Paper›PMID 25852575›Full record

ReviewFrontiers in physiology2015

Organization and dynamics of SNARE proteins in the presynaptic membrane.

Dragomir Milovanovic, Reinhard Jahn

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Assays of Platelet SNARE-actin Interactions.Methods in molecular biology (Clifton, N.J.) · 2025
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  16. Phosphatidic acid and neurotransmission.Advances in biological regulation · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dragomir MilovanovicDepartment of Neurobiology, Max Planck Institute for Biophysical Chemistry Göttingen, Germany.
Reinhard JahnDepartment of Neurobiology, Max Planck Institute for Biophysical Chemistry Göttingen, Germany.
Max Planck Institute for Biophysical Chemistry · DEMax Planck Society · DE

Funding

Structural Dynamics of the Exocytotic Fusion Machine in Neurons.P01GM072694 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KIESSLING, VOLKER · 2005 to 2021
$17.4M
NIGMS NIH HHS P01 GM072694
6 · The paper itself

Abstract

Our view of the lateral organization of lipids and proteins in the plasma membrane has evolved substantially in the last few decades. It is widely accepted that many, if not all, plasma membrane proteins and lipids are organized in specific domains. These domains vary widely in size, composition, and stability, and they represent platforms governing diverse cell functions. The presynaptic plasma membrane is a well-studied example of a membrane which undergoes rearrangements, especially during exo- and endocytosis. Many proteins and lipids involved in presynaptic function are known, and major efforts have been made to understand their spatial organization and dynamics. Here, we focus on the mechanisms underlying the organization of SNAREs, the key proteins of the fusion machinery, in distinct domains, and we discuss the functional significance of these clusters.

Indexed as

clusteringhydrophobic interactionsionic interactionsmembrane domainsmodularity of cluster formationSNARE proteins

Identifiers

PMID25852575
PMCPMC4365744
OpenAlexW1976869920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.