Evidence map›Paper›PMID 25852567›Full record

ArticleFrontiers in physiology2015

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study.

Ismail Adeniran, David H MacIver, Jules C Hancox, Henggui Zhang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04189029 (Redefining the Phenotypic Spectrum of Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04189029 unknown statusnot on this mapstarted 2019, after this paper: background citation

Redefining the Phenotypic Spectrum of Heart Failure With Preserved Ejection Fraction (HFpEF) by Deep Phenotyping and Machine Learning Methods: The PACIFIC-PRESERVED Study (PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study)

Typeobservational_patient_registrySponsorAssistance Publique - Hôpitaux de ParisRan2019 to 2025Enrolled175ConditionsHeart Failure, Heart Failure With Preserved Ejection FractionArmsExtensive phenotyping
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Changes of calcium cycling in HFrEF and HFpEF.Mechanobiology in medicine · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. RyR2 and Calcium Release in Heart Failure.Frontiers in physiology · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ismail AdeniranBiological Physics Group, School of Physics and Astronomy, The University of Manchester Manchester, UK.
David H MacIverBiological Physics Group, School of Physics and Astronomy, The University of Manchester Manchester, UK ; Department of Cardiology, Taunton and Somerset Hospital Musgrove Park, Taunton, UK.
Jules C HancoxBiological Physics Group, School of Physics and Astronomy, The University of Manchester Manchester, UK ; School of Physiology and Pharmacology and Cardiovascular Research Laboratories, School of Medical Sciences Bristol, UK.
Henggui ZhangBiological Physics Group, School of Physics and Astronomy, The University of Manchester Manchester, UK ; School of Computer Science and Technology, Harbin Institute of Technology Harbin, China.
University of Manchester · GBMusgrove Park Hospital · GB

Funding

British Heart Foundation FS/14/5/30533
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure cases. It has features of incomplete relaxation and increased stiffness of the left ventricle. Studies from clinical electrophysiology and animal experiments have found that HFpEF is associated with impaired calcium homeostasis, ion channel remodeling and concentric left ventricle hypertrophy (LVH). However, it is still unclear how the abnormal calcium homeostasis, ion channel and structural remodeling affect the electro-mechanical dynamics of the ventricles. In this study we have developed multiscale models of the human left ventricle from single cells to the 3D organ, which take into consideration HFpEF-induced changes in calcium handling, ion channel remodeling and concentric LVH. Our simulation results suggest that at the cellular level, HFpEF reduces the systolic calcium level resulting in a reduced systolic contractile force, but elevates the diastolic calcium level resulting in an abnormal residual diastolic force. In our simulations, these abnormal electro-mechanical features of the ventricular cells became more pronounced with the increase of the heart rate. However, at the 3D organ level, the ejection fraction of the left ventricle was maintained due to the concentric LVH. The simulation results of this study mirror clinically observed features of HFpEF and provide new insights toward the understanding of the cellular bases of impaired cardiac electromechanical functions in heart failure.

Indexed as

3D modelcalciumheart failureventricle

Identifiers

PMID25852567
PMCPMC4367530
OpenAlexW2079424164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.