ArticleFrontiers in human neuroscience2015
Dysfunctional Activation and Brain Network Profiles in Youth with Obsessive-Compulsive Disorder: A Focus on the Dorsal Anterior Cingulate during Working Memory.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- HIV chronicity as a predictor of hippocampal memory deficits in daily cannabis users living with HIV.Drug and alcohol dependence reports · 2023Article
- Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment.Psychoradiology · 2023Review
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
- Neural Correlates of Executive Functioning in Anorexia Nervosa and Obsessive-Compulsive Disorder.Frontiers in human neuroscience · 2022Review
- Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021Review
- Psychiatric disorders in multiple sclerosis.Journal of neurology · 2021Review
- Evoking network profiles of the dorsal anterior cingulate in youth with Obsessive-Compulsive Disorder during motor control and working memory.Journal of psychiatric research · 2021Article
- ALE meta-analysis, its role in node identification and the effects on estimates of local network organization.Brain structure & function · 2020Article
- Cortical-hippocampal functional connectivity during covert consolidation sub-serves associative learning: Evidence for an active "rest" state.Brain and cognition · 2019Article
- Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of the dorsal anterior cingulate cortex.Psychiatry research. Neuroimaging · 2017Article
- Tai Chi Chuan and Baduanjin practice modulates functional connectivity of the cognitive control network in older adults.Scientific reports · 2017Article
- Real-time functional magnetic resonance imaging in obsessive-compulsive disorder.Neuropsychiatric disease and treatment · 2017Review
- Article
- Developmental Neuroimaging in Pediatric Obsessive-Compulsive Disorder.Current behavioral neuroscience reports · 2016Article
- Network Profiles of the Dorsal Anterior Cingulate and Dorsal Prefrontal Cortex in Schizophrenia During Hippocampal-Based Associative Memory.Frontiers in systems neuroscience · 2016Article
- Cortico-Striato-Thalamo-Cortical Circuitry, Working Memory, and Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2016Article
- Cognitive and emotional impairments in obsessive-compulsive disorder: Evidence from functional brain alterations.Porto biomedical journalReview
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Authors and funding
7 authors.
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Abstract
Brain network dysfunction is emerging as a central biomarker of interest in psychiatry, in large part, because psychiatric conditions are increasingly seen as disconnection syndromes. Understanding dysfunctional brain network profiles in task-active states provides important information on network engagement in an experimental context. This in turn may be predictive of many of the cognitive and behavioral deficits associated with complex behavioral phenotypes. Here we investigated brain network profiles in youth with obsessive-compulsive disorder (OCD), contrasting them with a group of age-comparable controls. Network interactions were assessed during simple working memory: in particular, we focused on the modulation by the dorsal anterior cingulate cortex (dACC) of cortical, striatal, and thalamic regions. The focus on the dACC was motivated by its hypothesized role in the pathophysiology of OCD. However, its task-active network signatures have not been investigated before. Network interactions were modeled using psychophysiological interaction, a simple directional model of seed to target brain interactions. Our results indicate that OCD is characterized by significantly increased dACC modulation of cortical, striatal, and thalamic targets during working memory, and that this aberrant increase in OCD patients is maintained regardless of working memory demand. The results constitute compelling evidence of dysfunctional brain network interactions in OCD and suggest that these interactions may be related to a combination of network inefficiencies and dACC hyper-activity that has been associated with the phenotype.
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