ArticleFrontiers in neuroanatomy2015
A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model.
Article in Frontiers in neuroanatomy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93 citing papers in PubMed, 201 citations in OpenAlex.
- Reassessing forebrain organization: recent evidence challenges the prosomere model.Current opinion in genetics & development · 2026Review
- The developing midbrain-hindbrain boundary contains molecularly distinct cell populations.bioRxiv : the preprint server for biology · 2026Article
- Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell stem cell · 2026Article
- Review
- Anatomy of the hypothalamic-pituitary axis and buccal lobe in the holocephalan Callorhinchus callorynchus.Cell and tissue research · 2026Article
- Neuromeric Organization of the Microbat Brain: Conserved and Distinct Regional Features.The Journal of comparative neurology · 2026Article
- Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex.The Journal of comparative neurology · 2026Review
- Resolving forebrain developmental organisation by analysis of differential growth patterns.Nature communications · 2025Article
- Elucidating the neuromeric organization of the Mongolian gerbil brain.Brain structure & function · 2025Article
- Chemoarchitectural studies of the rat hypothalamus and zona incerta.bioRxiv : the preprint server for biology · 2025Article
- The expression of transcription factors in the human fetal subthalamic nucleus suggests its origin from the first hypothalamic prosomere.Brain structure & function · 2025Article
- Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and related forebrain centers.Frontiers in neuroanatomy · 2025Article
- Developmental and adult expression of the Meis2 transcription factor in the central nervous system ofFrontiers in neuroanatomy · 2025Article
- Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area.Frontiers in neuroanatomy · 2025Article
- The Spiraling Cognitive-Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization.Journal of cognitive neuroscience · 2024Article
- Can We Explain Thousands of Molecularly Identified Mouse Neuronal Types? From Knowing to Understanding.Biomolecules · 2024Review
- Functional Implications of the Prosomeric Brain Model.Biomolecules · 2024Article
- Ramón y Cajal's 'lenticular tract' represents infrasubthalamic pyramidal collaterals targeting mesodiencephalic centers: an obscure misunderstood aspect of the motor pathway clarified by Allen Mouse Brain Connectivity data.Frontiers in neuroanatomy · 2024Article
- Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum.The Journal of comparative neurology · 2023Article
- The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.International journal of molecular sciences · 2023Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this essay, we aim to explore in depth the new concept of the hypothalamus that was presented in the updated prosomeric model (Puelles et al., 2012b; Allen Developing Mouse Brain Atlas). Initial sections deal with the antecedents of prosomeric ideas represented by the extensive literature centered on the alternative columnar model of Herrick (1910), Kuhlenbeck (1973) and Swanson (1992, 2003); a detailed critique explores why the columnar model is not helpful in the search for causal developmental explanations. In contrast, the emerging prosomeric scenario visibly includes many possibilities to propose causal explanations of hypothalamic structure relative to both anteroposterior and dorsoventral patterning mechanisms, and insures the possibility to compare hypothalamic histogenesis with that of more caudal parts of the brain. Next the four major changes introduced in the organization of the hypothalamus on occasion of the updated model are presented, and our rationale for these changes is explored in detail. It is hoped that this example of morphological theoretical analysis may be useful for readers interested in brain models, or in understanding why models may need to change in the quest for higher consistency.
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