ReviewFrontiers in neuroscience2015
Local modulation of steroid action: rapid control of enzymatic activity.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- Benefits of aromatase blockers for increased testosterone in poultry: A mini-review.Veterinary world · 2025Review
- Rapid and local neuroestrogen synthesis supports long-term potentiation of hippocampal Schaffer collaterals-cornu ammonis 1 synapse in ovariectomized mice.Journal of neuroendocrinology · 2024Article
- Review
- Growth, pectoralis muscle performance, and testis of pelung cockerels (Veterinary world · 2023Article
- A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis.Neurology and therapy · 2022Review
- Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy.Journal of neuroendocrinology · 2022Review
- Concentrations of estradiol, progesterone and testosterone in sefrum and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage correlate weakly with transcranial Doppler flow velocities.BMC neuroscience · 2021Article
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- Estrogen Formation and Inactivation Following TBI: What we Know and Where we Could go.Frontiers in endocrinology · 2020Review
- Serotonin and serotonin reuptake inhibitors alter placental aromatase.The Journal of steroid biochemistry and molecular biology · 2019Article
- Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males.BMC neuroscience · 2019Article
- Defining the Construct of Synthetic Androgen Intoxication: An Application of General Brain Arousal.Frontiers in psychology · 2018Article
- Topography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sex and the development of Alzheimer's disease.Journal of neuroscience research · 2017Review
- Rodent Models of Non-classical Progesterone Action Regulating Ovulation.Frontiers in endocrinology · 2017Review
- Actions of Steroids: New Neurotransmitters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Aromatase inhibition rapidly affects in a reversible manner distinct features of birdsong.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17β-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.