ArticleFrontiers in neuroscience2015
Effect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Social deprivation weakens sender-receiver coupling in mother-infant acoustic communication by altering pup vocal development in Mongolian gerbils (Meriones unguiculatus).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia.Scientific reports · 2025Article
- Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study.Frontiers in psychiatry · 2025Article
- Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior.Scientific reports · 2024Article
- Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits.Molecular autism · 2024Article
- Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review.Brain sciences · 2024Article
- Sociability versus empathy in adolescent mice: Different or distinctive?Learning and motivation · 2023Article
- Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy.International journal of molecular sciences · 2023Review
- The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice.Frontiers in molecular neuroscience · 2023Article
- Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups.Frontiers in behavioral neuroscience · 2022Article
- Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies.Neural regeneration research · 2021Review
- Automatic classification of mice vocalizations using Machine Learning techniques and Convolutional Neural Networks.PloS one · 2021Article
- Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder.Behavioural brain research · 2019Article
- Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.Frontiers in behavioral neuroscience · 2018Article
- Impaired Object Recognition but Normal Social Behavior and Ultrasonic Communication in Cofilin1 Mutant Mice.Frontiers in behavioral neuroscience · 2018Article
- Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.Scientific reports · 2017Article
- High-precision spatial localization of mouse vocalizations during social interaction.Scientific reports · 2017Article
- Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats.PloS one · 2016Article
- Neuronal correlates of asocial behavior in a BTBR T (+) Itpr3(tf)/J mouse model of autism.Frontiers in behavioral neuroscience · 2015Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
An important diagnostic criterion for social communication deficits in autism spectrum disorders (ASD) are difficulties in adjusting behavior to suit different social contexts. While the BTBR T+tf/J (BTBR) inbred strain of mice is one of the most commonly used mouse models for ASD, little is known about whether BTBR mice display deficits in detecting changes in social context and their ability to adjust to them. Here, it was tested therefore whether the emission of isolation-induced ultrasonic vocalizations (USV) in BTBR mouse pups is affected by the social odor context, in comparison to the standard control strain with high sociability, C57BL/6J (B6). It is known that the presence of odors from mothers and littermates leads to a calming of the isolated mouse pup, and hence to a reduction in isolation-induced USV emission. In accordance with their behavioral phenotypes with relevance to all diagnostic core symptoms of ASD, it was predicted that BTBR mouse pups would not display a calming response when tested under soiled bedding conditions with home cage bedding material containing maternal odors, and that similar isolation-induced USV emission rates would be seen in BTBR mice tested under clean and soiled bedding conditions. Unexpectedly, however, the present findings show that BTBR mouse pups display such a calming response and emit fewer isolation-induced USV when tested under soiled as compared to clean bedding conditions, similar to B6 mouse pups. Yet, in contrast to B6 mouse pups, which emitted isolation-induced USV with shorter call durations and lower levels of frequency modulation under soiled bedding conditions, social odor context had no effect on acoustic call features in BTBR mouse pups. This indicates that the BTBR mouse model for ASD does not display deficits in detecting changes in social context, but has a limited ability and/or reduced motivation to adjust to them.
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