Evidence map›Paper›PMID 25852293›Full record

ArticleWorld journal of gastroenterology2015

Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis.

J Todd Kuenstner, William Chamberlin, Saleh A Naser, Michael T Collins, Coad Thomas Dow, John M Aitken, Stuart Weg, Grzegorz Telega, Kuruvilla John, David Haas and 4 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Frontiers in cellular and infection microbiology · 2022
    Article
  6. Article
  7. Use of Ultraviolet Blood Irradiation Against Viral Infections.Clinical reviews in allergy & immunology · 2021
    Review
  8. Frontiers in public health · 2021
    Article
  9. Article
  10. Open veterinary journal · 2018
    Review
  11. Review
  12. Article
  13. The Consensus from theFrontiers in public health · 2017
    Article
  14. Review
  15. Article
  16. Mycobacterium paratuberculosis as a cause of Crohn's disease.Expert review of gastroenterology & hepatology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

J Todd KuenstnerJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
William ChamberlinJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Saleh A NaserJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Michael T CollinsJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Coad Thomas DowJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
John M AitkenJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Stuart WegJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Grzegorz TelegaJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Kuruvilla JohnJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
David HaasJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Torsten M EcksteinJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Maher KaliJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Christine WelchJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Thomas PetrieJ Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
Charleston Area Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.

Indexed as

AdultAntitubercular AgentsBacteriological TechniquesBiopsyChildColonoscopyCombined Modality TherapyComplex Regional Pain SyndromesCrohn DiseaseFemaleHumansMaleMycobacterium avium subsp. paratuberculosisParatuberculosisRemission InductionTreatment OutcomeAntitubercular AgentsComplex regional pain syndromeCrohn’s diseaseCureLymphangiomatosisMycobacterium avium paratuberculosis

Identifiers

PMID25852293
PMCPMC4385555
OpenAlexW2113787300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.