Evidence map›Paper›PMID 25852287›Full record

Observational studyWorld journal of gastroenterology2015

Rectal tone and compliance affected in patients with fecal incontinence after fistulotomy.

Richard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García

Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04716738 (Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04716738 unknown statusnot on this mapstarted 2023, after this paper: background citation

Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome

Typeobservational_patient_registrySponsorHospital General de MexicoRan2023 to 2023Enrolled20ConditionsIrritable Bowel Syndrome, Sexual DysfunctionArmsBlood analyses and coprological
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Richard Alexander AwadRichard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García, Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, Mexico DF06726, Mexico.
Santiago CamachoRichard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García, Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, Mexico DF06726, Mexico.
Francisco FloresRichard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García, Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, Mexico DF06726, Mexico.
Evelyn AltamiranoRichard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García, Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, Mexico DF06726, Mexico.
Mario Antonio GarcíaRichard Alexander Awad, Santiago Camacho, Francisco Flores, Evelyn Altamirano, Mario Antonio García, Experimental Medicine and Motility Unit, Gastroenterology Service U-107, Mexico City General Hospital, Mexico DF06726, Mexico.
Hospital General de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the anal sphincter and rectal factors that may be involved in fecal incontinence that develops following fistulotomy (FIAF).

methodsEleven patients with FIAF were compared with 11 patients with idiopathic fecal incontinence and with 11 asymptomatic healthy subjects (HS). All of the study participants underwent anorectal manometry and a barostat study (rectal sensitivity, tone, compliance and capacity). The mean time since surgery was 28 ± 26 mo. The postoperative continence score was 14 ± 2.5 (95%CI: 12.4-15.5, St Mark's fecal incontinence grading system).

resultsCompared with the HS, the FIAF patients showed increased rectal tone (42.63 ± 27.69 vs 103.5 ± 51.13, P = 0.002) and less rectal compliance (4.95 ± 3.43 vs 11.77 ± 6.9, P = 0.009). No significant differences were found between the FIAF patients and the HS with respect to the rectal capacity; thresholds for the non-noxious stimuli of first sensation, gas sensation and urge-to-defecate sensation or the noxious stimulus of pain; anal resting pressure or squeeze pressure; or the frequency or percentage of relaxation of the rectoanal inhibitory reflex. No significant differences were found between the FIAF patients and the patients with idiopathic fecal incontinence.

conclusionIn patients with FIAF, normal motor anal sphincter function and rectal sensitivity are preserved, but rectal tone and compliance are impaired. The results suggest that FIAF is not due to alterations in rectal sensitivity and that the rectum is more involved than the anal sphincters in the genesis of FIAF.

Indexed as

AdolescentAdultAgedAnal CanalCase-Control StudiesComplianceDigestive System Surgical ProceduresFecal IncontinenceFemaleHumansMaleManometryMechanotransduction, CellularMiddle AgedPressureRectal FistulaAnorectal surgeryBarostatFecal incontinenceFistulotomyVisceral sensitivity

Identifiers

PMID25852287
PMCPMC4385549
OpenAlexW2332050928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.