Evidence map›Paper›PMID 25852276›Full record

ArticleWorld journal of gastroenterology2015

Hepatitis C virus recurrence after liver transplantation: a 10-year evaluation.

Stefano Gitto, Luca Saverio Belli, Ranka Vukotic, Stefania Lorenzini, Aldo Airoldi, Arrigo Francesco Giuseppe Cicero, Marcello Vangeli, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Efficacy and Safety of Daclatasvir in Hepatitis C: An Overview.Journal of clinical and translational hepatology · 2016
    Review
  4. Article
  5. Post liver transplant recurrent and de novo viral infections.Best practice & research. Clinical gastroenterology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stefano GittoStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Luca Saverio BelliStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Ranka VukoticStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Stefania LorenziniStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Aldo AiroldiStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Arrigo Francesco Giuseppe CiceroStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Marcello VangeliStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Lucia BrodosiStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Arianna Martello PannoStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Roberto Di DonatoStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Matteo CesconStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Gian Luca GraziStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Luciano De CarlisStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Antonio Daniele PinnaStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Mauro BernardiStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.
Pietro AndreoneStefano Gitto, Ranka Vukotic, Stefania Lorenzini, Arrigo Francesco Giuseppe Cicero, Lucia Brodosi, Arianna Martello Panno, Roberto Di Donato, Matteo Cescon, Gian Luca Grazi, Antonio Daniele Pinna, Mauro Bernardi, Pietro Andreone, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, 40138 Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the predictors of 10-year survival of patients with hepatitis C recurrence.

methodsData from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ(2), Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.

resultsThe ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status (mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different (59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders" (84.7% vs 39.8%, P < 0.0001) and too sick to be treated (84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence (84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival.

conclusionSustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

Indexed as

Liver TransplantationAdultAntiviral AgentsChi-Square DistributionDrug Therapy, CombinationEnd Stage Liver DiseaseFemaleHepacivirusHepatitis CHumansItalyKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisAntiviral AgentsAntiviral treatmentHepatitis CHepatitis C virus recurrenceLiver transplantationTen-year survival

Identifiers

PMID25852276
PMCPMC4385538

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