Evidence map›Paper›PMID 25852265›Full record

ReviewWorld journal of gastroenterology2015

Gastrointestinal Behçet's disease: a review.

Wasseem Skef, Matthew J Hamilton, Thurayya Arayssi

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03274648 nacompletednot on this mapstarted 2017, after this paper: background citation

Therapeutic Modulation of Butyrate Production in Behçet's Patients: a Dietary Intervention Trial

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria CareggiRan2017 to 2019Enrolled17ConditionsBehcet SyndromeArmsOral butyrate, Vegetarian diet, Habitual diet
NCT03962335 nacompletednot on this mapstarted 2019, after this paper: background citation

ModulAtion of Gut Microbiota Through Nutritional Interventions in Behcet's Syndrome pAtients: the MAMBA Study

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria CareggiRan2019 to 2023Enrolled90ConditionsBehcet SyndromeArmsVegetarian diet, Mediterranean diet with butyrate, Mediterranean diet
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it, 211 citations in OpenAlex.

  1. IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases.International journal of molecular sciences · 2019
    Pooled it
  2. Article
  3. Stricturing Diseases of the Gastrointestinal Tract-Current Clinical Practice.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Article
  18. The research progress of LACC1.Frontiers in immunology · 2025
    Review
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wasseem SkefWasseem Skef, Department of Medicine, St. Elizabeth's Medical Center, Boston, MA 02135, United States.
Matthew J HamiltonWasseem Skef, Department of Medicine, St. Elizabeth's Medical Center, Boston, MA 02135, United States.
Thurayya ArayssiWasseem Skef, Department of Medicine, St. Elizabeth's Medical Center, Boston, MA 02135, United States.
St. Elizabeth's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. Prevalence of BD is highest in countries along the ancient silk road from the Mediterranean basin to East Asia. By comparison, the prevalence in North American and Northern European countries is low. Gastrointestinal manifestations of Behçet's disease are of particular importance as they are associated with significant morbidity and mortality. Although ileocecal involvement is most commonly described, BD may involve any segment of the intestinal tract as well as the various organs within the gastrointestinal system. Diagnosis is based on clinical criteria - there are no pathognomonic laboratory tests. Methods for monitoring disease activity on therapy are available but imperfect. Evidence-based treatment strategies are lacking. Different classes of medications have been successfully used for the treatment of intestinal BD which include 5-aminosalicylic acid, corticosteroids, immunomodulators, and anti-tumor necrosis factor alpha monoclonal antibody therapy. Like inflammatory bowel disease, surgery is reserved for those who are resistant to medical therapy. A subset of patients have a poor disease course. Accurate methods to detect these patients and the optimal strategy for their treatment are not known at this time.

Indexed as

Behcet SyndromeGastrointestinal DiseasesAnimalsDiagnosis, DifferentialHumansPredictive Value of TestsPrevalenceRisk FactorsSeverity of Illness IndexTreatment OutcomeBehçet diseaseBehçet syndromeInflammatory bowel diseaseLower gastrointestinal tractUlcerUpper gastrointestinal tract

Identifiers

PMID25852265
PMCPMC4385527
OpenAlexW1980452914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.