ArticleDiabetes care2015
Genetic Predisposition to Central Obesity and Risk of Type 2 Diabetes: Two Independent Cohort Studies.
Article in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extensive Review of Persuasive System Design Categories and Principles: Behavioral Obesity Interventions.Journal of medical systems · 2020Pooled it
- Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.Cardiovascular diabetology · 2026Trial
- Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial.European journal of nutrition · 2021Trial
- Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial.Diabetologia · 2021Trial
- Habitual consumption of long-chain n-3 PUFAs and fish attenuates genetically associated long-term weight gain.The American journal of clinical nutrition · 2019Trial
- Trial
- Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.The American journal of clinical nutrition · 2016Trial
- Long-term metabolic-adiposity burden and cardiovascular risk: the cumTyG-WHtR in Chinese adults.BMC cardiovascular disorders · 2026Article
- Sarcopenic obesity increases the risk of falls in early-onset type 2 diabetes.Journal of endocrinological investigation · 2026Article
- A correlation analysis between TyG-derived indices and diabetes mellitus: based on the NHANES database.Endocrine journal · 2026Article
- Associations of six adiposity indices with incident back pain and the mediating role of the triglyceride-glucose index: prospective findings from the UK biobank.Frontiers in nutrition · 2026Article
- Enhanced prediction of cholecystectomy using obesity-modified TyG indices: a machine learning and SHAP-based study.European journal of medical research · 2025Article
- Meat and fish consumption, genetic risk and risk of severe metabolic-associated fatty liver disease: a prospective cohort of 487,875 individuals.Nutrition journal · 2025Article
- Article
- Triglyceride glucose index - body mass index predicts insulin resistance, metabolic syndrome and associates with impaired ovulation in Chinese women with polycystic ovary syndrome.Frontiers in endocrinology · 2025Article
- Article
- Synergistic effects of triglyceride-glucose index and body mass index combined with depression in predicting stroke events: a study based on two national cohorts.Frontiers in nutrition · 2025Article
- Association between triglyceride-glucose index and its correlation indexes and stress urinary incontinence in postmenopausal women: evidence from NHANES 2005-2018.Lipids in health and disease · 2024Article
- Continuous Glucose Monitoring-New Diagnostic Tool in Complex Pathophysiological Disorder of Glucose Metabolism in Children and Adolescents with Obesity.Diagnostics (Basel, Switzerland) · 2024Review
- Associations of circulating total p-cresylsulfate and indoxyl sulfate concentrations with central obesity in patients with stable coronary artery disease: sex-specific insights.International journal of obesity (2005) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveAbdominal obesity is a major risk factor for type 2 diabetes (T2D). We aimed to examine the association between the genetic predisposition to central obesity, assessed by the waist-to-hip ratio (WHR) genetic score, and T2D risk. RESEARCH DESIGN AND
methodsThe current study included 2,591 participants with T2D and 3,052 participants without T2D of European ancestry from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Genetic predisposition to central obesity was estimated using a genetic score based on 14 established loci for the WHR.
resultsWe found that the central obesity genetic score was linearly related to higher T2D risk. Results were similar in the NHS (women) and HPFS (men). In combined results, each point of the central obesity genetic score was associated with an odds ratio (OR) of 1.04 (95% CI 1.01-1.07) for developing T2D, and the OR was 1.24 (1.03-1.45) when comparing extreme quartiles of the genetic score after multivariate adjustment.
conclusionsThe data indicate that genetic predisposition to central obesity is associated with higher T2D risk. This association is mediated by central obesity.
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