ReviewEuropean journal of radiology2015
Ultrasound molecular imaging: Moving toward clinical translation.
Review in European journal of radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 208 citations in OpenAlex.
- Improved Nondestructive Ultrasound Molecular Imaging With Lightweight Convolutional Neural Network.IEEE transactions on medical imaging · 2026Article
- Application of ultrasound and ultrasound-responsive materials in wounds: A systematic review.International journal of pharmaceutics: X · 2026Review
- Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Enhancing Ultrasound Molecular Imaging: Toward Real-Time RPCA-Based Filtering to Differentiate Bound and Free Microbubbles.IEEE transactions on ultrasonics · 2025Article
- Quantifying Molecular Changes in the Preeclamptic Rat Placenta with Targeted Contrast-Enhanced Ultrasound Imaging.Molecular imaging and biology · 2025Article
- Predictive nomogram of ultrasound indicators for the termination outcome of caesarean scar pregnancy.Scientific reports · 2024Article
- Ultrasound Molecular Imaging Enhances High-Intensity Focused Ultrasound Ablation on Liver Cancer With B7-H3-Targeted Microbubbles.Cancer medicine · 2024Article
- Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging.Journal of nanobiotechnology · 2024Article
- Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material.Microsystems & nanoengineering · 2024Article
- Multiplex Ultrasound Imaging of Perfluorocarbon Nanodroplets Enabled by Decomposition of Postvaporization Dynamics.Nano letters · 2024Article
- Nanotechnology based gas delivery system: a "green" strategy for cancer diagnosis and treatment.Theranostics · 2024Review
- The Current Status and Future Directions on Nanoparticles for Tumor Molecular Imaging.International journal of nanomedicine · 2024Review
- Exploring the potential of contrast agents in breast cancer echography: current state and future directions.Journal of ultrasound · 2023Review
- Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine.Journal of biomedical optics · 2023Review
- Review
- Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Monodispersity Increases Adhesion Efficiency and Specificity for Ultrasound-Targeted Microbubbles.ACS biomaterials science & engineering · 2023Article
- Nanomedicine for renal cell carcinoma: imaging, treatment and beyond.Journal of nanobiotechnology · 2023Review
- Ultrasound Molecular Imaging of Bladder Cancer via Extradomain B Fibronectin-Targeted Biosynthetic GVs.International journal of nanomedicine · 2023Article
- Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles.Frontiers in bioengineering and biotechnology · 2023Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasound is a widely available, cost-effective, real-time, non-invasive and safe imaging modality widely used in the clinic for anatomical and functional imaging. With the introduction of novel molecularly-targeted ultrasound contrast agents, another dimension of ultrasound has become a reality: diagnosing and monitoring pathological processes at the molecular level. Most commonly used ultrasound molecular imaging contrast agents are micron sized, gas-containing microbubbles functionalized to recognize and attach to molecules expressed on inflamed or angiogenic vascular endothelial cells. There are several potential clinical applications currently being explored including earlier detection, molecular profiling, and monitoring of cancer, as well as visualization of ischemic memory in transient myocardial ischemia, monitoring of disease activity in inflammatory bowel disease, and assessment of arteriosclerosis. Recently, a first clinical grade ultrasound contrast agent (BR55), targeted at a molecule expressed in neoangiogenesis (vascular endothelial growth factor receptor type 2; VEGFR2) has been introduced and safety and feasibility of VEGFR2-targeted ultrasound imaging is being explored in first inhuman clinical trials in various cancer types. This review describes the design of ultrasound molecular imaging contrast agents, imaging techniques, and potential future clinical applications of ultrasound molecular imaging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.