Evidence map›Paper›PMID 25851931›Full record

Observational studyJournal of gastroenterology2015

Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study.

Nobuyuki Matsuhashi, Mineo Kudo, Norimasa Yoshida, Kazunari Murakami, Mototsugu Kato, Tsuyoshi Sanuki, Atsushi Oshio, Takashi Joh, Kazuhide Higuchi, Ken Haruma and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 1 country.

Nobuyuki MatsuhashiDepartment of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Mineo KudoDepartment of Gastroenterology, Sapporo Hokuyu Hospital, 6-5-1 Higashisapporo 6-jo, Shiroishi-ku, Sapporo, Hokkaido, 003-0006, Japan.
Norimasa YoshidaDepartment of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital, 15-749 Hommachi, Higashiyama-ku, Kyoto, 605-0981, Japan.
Kazunari MurakamiDepartment of Gastroenterology, Oita University Hospital, 1-1 Hasamamachi Idaigaoka, Yufu, Oita, 879-5593, Japan.
Mototsugu KatoDivision of Endoscopy, Hokkaido University Hospital, 5-chome, Kita14-jo Nishi, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan.
Tsuyoshi SanukiDepartment of Gastroenterology, Kita Harima Medical Center, 926-250 Ichiba, Ono, Hyogo, 675-1392, Japan.
Atsushi OshioFaculty of Letters, Arts and Sciences, Waseda University, 1-24-1 Toyama, Shinjuku-ku, Tokyo, 162-8644, Japan.
Takashi JohDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi Mizuhocho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Kazuhide HiguchiGERD Society Study Committee, 2-2-2 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan.
Ken HarumaGERD Society Study Committee, 2-2-2 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan.
Koji NakadaGERD Society Study Committee, 2-2-2 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan. nakada@jikei.ac.jp.
Hokkaido University Hospital · JPKawasaki Medical School · JPKyoto first Red Cross hospital · JPNagoya City University · JPNTT Medical Center · JPOita University Hospital · JPOsaka Medical and Pharmaceutical University · JPSapporo Hokuyu Hospital · JPTokyo-Kita Medical Center · JPWaseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.

methodsJapanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients' characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.

resultsData from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (p < 0.05), absence of erosive esophagitis (p < 0.05), higher epigastric pain/burning symptom score (p < 0.05), and higher depression subscale score (p < 0.05) accompanied poorer therapeutic response. In analyses using the patient's impression of therapy, lower GERD symptom score (p < 0.05) and absence of erosive esophagitis (p < 0.05) accompanied poorer therapeutic response. In analyses using the relative GERD symptom intensity evaluated using a numeric rating scale, lower GERD symptom score (p < 0.05), higher epigastric pain/burning symptom score (p < 0.1), and lower body mass index (p < 0.05) accompanied poorer therapeutic response.

conclusionsPatients who complained of milder GERD symptoms before treatment were likely to have poorer response to PPI therapy. Association of absence of erosive esophagitis, severer epigastric pain/burning symptoms, lower body mass index, and severer depression with poorer therapeutic response was also suggested.

Indexed as

AdultAgedAge DistributionAnxietyDepressionDyspepsiaFemaleGastroesophageal RefluxHumansMaleMiddle AgedPatient SatisfactionProspective StudiesProton Pump InhibitorsSeverity of Illness IndexSex DistributionProton Pump InhibitorsAnxietyDepressionDyspeptic symptomsGastroesophageal reflux diseaseTherapeutic response to proton pump inhibitor therapy

Identifiers

PMID25851931
OpenAlexW1987123474

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.