ArticleJournal of the American Geriatrics Society2015
The microbiota and microbiome in aging: potential implications in health and age-related diseases.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 3 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults: A Systematic Review.Nutrients · 2024Pooled it
- Gut microbiome and frailty: insight from genetic correlation and mendelian randomization.Gut microbes · 2023Pooled it
- The Gut Microbiome, Aging, and Longevity: A Systematic Review.Nutrients · 2020Pooled it
- From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy.Journal of cosmetic dermatology · 2019Trial
- Understanding The Role of Lacticaseibacillus rhamnosus in Vaginal Dysbiosis: in Vitro Studies and Clinical Evidence.Probiotics and antimicrobial proteins · 2026Review
- The Gut Microbiome in Amyotrophic Lateral Sclerosis: Emerging Mechanisms and Therapeutic Potential.Molecular neurobiology · 2026Review
- Gut Microbiota Affects Age-Related Plasma Metabolites.Microorganisms · 2026Article
- Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.Nature aging · 2026Article
- Endocrine-disrupting chemicals in cosmetics: mechanistic insights and their impact on human and skin health.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- Intratumoral Microbiome-Tumor Microenvironment Crosstalk in Breast Cancer Aggressiveness.The breast journal · 2026Review
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Different ages of gut microbiota diversity and metabolic pattern in rhesus macaques.Frontiers in microbiology · 2026Article
- Long COVID and gut microbiome: insights into pathogenesis and therapeutics.Gut microbes · 2025Review
- Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.GeroScience · 2025Article
- Synbiotic supplementation enhances memory processes in adult and aged male rats.Biogerontology · 2025Article
- Age-Related Cognitive Decline and Dementia: Interface of Microbiome-Immune-Neuronal Interactions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Review
- Antioxidant Activities of the Cell-Free Supernatant of a Potential Probiotic Cutibacterium acnes Strain CCSM0331, Isolated From a Healthy Skin.Journal of cosmetic dermatology · 2025Article
- Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats.Immunity & ageing : I & A · 2025Article
- Changes in the gut microbiome of older adults according to hypertension control.Frontiers in microbiology · 2025Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Advances in bacterial deoxyribonucleic acid sequencing allow for characterization of the human commensal bacterial community (microbiota) and its corresponding genome (microbiome). Surveys of healthy adults reveal that a signature composite of bacteria characterizes each unique body habitat (e.g., gut, skin, oral cavity, vagina). A myriad of clinical changes, including a basal proinflammatory state (inflamm-aging), that directly interface with the microbiota of older adults and enhance susceptibility to disease accompany aging. Studies in older adults demonstrate that the gut microbiota correlates with diet, location of residence (e.g., community dwelling, long-term care settings), and basal level of inflammation. Links exist between the microbiota and a variety of clinical problems plaguing older adults, including physical frailty, Clostridium difficile colitis, vulvovaginal atrophy, colorectal carcinoma, and atherosclerotic disease. Manipulation of the microbiota and microbiome of older adults holds promise as an innovative strategy to influence the development of comorbidities associated with aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.