ReviewAsian journal of andrology
The hazardous effects of tobacco smoking on male fertility.
Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Association Analysis and Meta-Analysis of Multi-Allelic Variants for Large-Scale Sequence Data.Genes · 2020Pooled it
- Paternal Smoking Before Conception and During Pregnancy Is Associated With an Increased Risk of Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of 17 Case-Control Studies.Journal of pediatric hematology/oncology · 2020Pooled it
- Impact of coenzyme Q10 as an adjuvant therapy to letrozole on spermiogram results and sex hormone levels in Iraqi men with infertility; randomized open label comparative study.F1000Research · 2023Trial
- Dietary patterns and testosterone balance: a review of clinical data and perspectives.Journal of advanced research · 2026Review
- Associations of Lifestyle Factors with Cadmium and Nickel in Seminal Fluid of Potential Sperm Donors.Biological trace element research · 2026Article
- Occupational and Lifestyle Factors of Male and Female Infertility Patients: Do They Impact ART Success?Medicina (Kaunas, Lithuania) · 2026Article
- Male Infertility: A Comprehensive Review of Urological Causes and Contemporary Management.Journal of clinical medicine · 2026Review
- Environmental and Genetic Perturbations of the Sperm Epigenome.Advances in experimental medicine and biology · 2026Review
- Article
- Effect of fermented red bean extract (Open veterinary journal · 2025Article
- Observational
- Unmasking the Epigenome: Insights into Testicular Cell Dynamics and Reproductive Function.International journal of molecular sciences · 2025Review
- Impact of Tobacco Cigarette Smoking on Semen Quality and Serum Levels of Sex Hormones in Men: A Cross-Sectional Population-Based Study.Health science reports · 2025Article
- Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.The world journal of men's health · 2025Review
- Can lifestyle changes significantly improve male fertility: A narrative review?Arab journal of urology · 2025Review
- Determinants of successful smoking cessation in outpatient settings: A comparative analysis of varenicline and free program interventions.Tobacco induced diseases · 2025Article
- Semen Quality Measures in Hookah and Cigarette Smokers Compared to Nonsmokers.TheScientificWorldJournal · 2025Article
- Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025Article
- Impact of Oxidative Stress on Sperm Quality in Oligozoospermia and Normozoospermia Males Without Obvious Causes of Infertility.Journal of clinical medicine · 2024Article
- Association between serum cotinine and total testosterone in adult males based on NHANES 2011-2016.Scientific reports · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The substantial harmful effects of tobacco smoking on fertility and reproduction have become apparent but are not generally appreciated. Tobacco smoke contains more than 4000 kinds of constituents, including nicotine, tar, carbonic monoxide, polycyclic aromatic hydrocarbons, and heavy metals. Because of the complexity of tobacco smoke components, the toxicological mechanism is notably complicated. Most studies have reported reduced semen quality, reproductive hormone system dysfunction and impaired spermatogenesis, sperm maturation, and spermatozoa function in smokers compared with nonsmokers. Underlying these effects, elevated oxidative stress, DNA damage, and cell apoptosis may play important roles collaboratively in the overall effect of tobacco smoking on male fertility. In this review, we strive to focus on both the phenotype of and the molecular mechanism underlying these harmful effects, although current studies regarding the mechanism remain insufficient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.