Evidence map›Paper›PMID 25851449›Full record

ArticleDevelopment and psychopathology2016

Trajectories of relationship stress and inflammatory processes in adolescence.

Katherine B Ehrlich, Gregory E Miller, Nicolas Rohleder, Emma K Adam

Abstract read
In one paragraph

Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. From the Cradle to the Grave: The Effect of Adverse Caregiving Environments on Attachment and Relationships Throughout the Lifespan.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2017
    Article
  12. The impact of stress at different life stages on physical health and the buffering effects of maternal sensitivity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine B EhrlichNorthwestern University.
Gregory E MillerNorthwestern University.
Nicolas RohlederBrandeis University.
Emma K AdamNorthwestern University.

Funding

Biological Embedding of Early-Life SESR01HD058502 · NICHD · UNIVERSITY OF BRITISH COLUMBIA · PI MILLER, GREGORY EVAN · 2009 to 2013
$1.3M
Adolescent Social Relationships and Immune, Endocrine, and Metabolic ProcessesF32HD076563 · NICHD · NORTHWESTERN UNIVERSITY · PI EHRLICH, KATHERINE BABCOCK · 2013 to 2014
$99k
CIHR 67191NICHD NIH HHS F32 HD076563NICHD NIH HHS HD058502NICHD NIH HHS HD76563NICHD NIH HHS R01 HD058502
6 · The paper itself

Abstract

Researchers have identified cross-sectional links between interpersonal stress and inflammation. Little is known, however, about how these dynamics unfold over time, what underlying immune pathways might exist, or whether moderators such as race could alter the strength of the connection between interpersonal stress and inflammatory processes. We examined whether adolescent girls whose relationship trajectories were characterized by chronic stress would exhibit a proinflammatory phenotype marked by systemic inflammation, heightened cytokine responses to bacterial challenges, and resistance to the anti-inflammatory properties of cortisol. Significant Stress × Race interactions revealed that family stress trajectories predicted glucocorticoid sensitivity and peer stress trajectories predicted cytokine production for White but not Asian girls. Relationship stress trajectories were not associated with systemic inflammation, however. These findings suggest that particular subgroups of adolescent girls who face chronic and elevated stress in their close relationships may be at risk for disruptions to the immune system.

Indexed as

Family RelationsInterpersonal RelationsPeer GroupAdolescentAnti-Inflammatory AgentsAsianC-Reactive ProteinCross-Sectional StudiesFemaleHumansHydrocortisoneInflammationInterleukin-6LipopolysaccharidesMonocytesStress, PsychologicalAnti-Inflammatory AgentsC-Reactive ProteinHydrocortisoneIL6 protein, humanInterleukin-6Lipopolysaccharides

Identifiers

PMID25851449
PMCPMC9188665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.