Evidence map›Paper›PMID 25851383›Full record

Trial reportIntensive care medicine2015

Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial.

Geetha Kayambu, Robert Boots, Jennifer Paratz

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04368117 (STAT), which is not on this map. Cited by 94 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 12 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04368117 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

STAT: Standard Therapy Plus Active Therapy to Improve Mobility, Long-Term Activity, and Quality of Life for Severely Burn Injured Patients After Skin Graft Surgery

TypeinterventionalSponsorAmerican Burn AssociationRan2020 to 2026Enrolled166ConditionsBurn Injury, Physical Injury, Thermal BurnArmsPhysical Therapy
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 12 syntheses or guidelines pooled it, 226 citations in OpenAlex.

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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Geetha KayambuSchool of Medicine, Burns, Trauma and Critical Care Research Centre, The Royal Brisbane and Women's Hospital, The University of Queensland, Level 7, Block 6, Herston, Brisbane, QLD, 4029, Australia, g.kayambu@uq.edu.au.
Robert Boots
Jennifer Paratz
Griffith University · AURoyal Brisbane and Women's Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleSurvivors of sepsis syndromes have poor outcomes for physical and cognitive function. No investigations of early physical rehabilitation in the intensive care unit have specifically targeted patients with sepsis syndromes.

objectiveTo determine whether early physical rehabilitation improves physical function and associated outcomes in patients with sepsis syndromes.

methodsFifty critically ill adults admitted to a general intensive care unit with sepsis syndromes were recruited into a prospective double-blinded randomised controlled trial investigating early physical rehabilitation. MEASUREMENTS: Primary outcomes of physical function (acute care index of function) and self-reported health-related quality of life were recorded at ICU discharge and 6 months post-hospital discharge, respectively. Secondary measures included inflammatory biomarkers; Interleukin-6, Interleukin-10 and tumour necrosis factor-α, blood lactate, fat-free muscle mass, exercise capacity, muscle strength and anxiety. MAIN

resultsA significant increase in patient self-reported physical function (81.8 ± 22.2 vs. 60.0 ± 29.4), p = 0.04) and physical role (61.4 ± 43.8 vs. 17.1 ± 34.4, p = 0.005) for the SF-36 at 6 months was found in the exercise group. Physical function scores were not significantly different between groups. Muscle strength scores were (51.9 ± 10.5 vs. 47.3 ± 13.6, p = 0.24) with the standard care mean Medical Research Council Muscle Score (MRC) <48/60. The mean change of Interleukin-10 increased and was significantly higher in the exercise group (1.8 pg/ml, 180 % vs. 0.9 pg/ml, 90 %, p = 0.04). There was no significant difference between groups for lactate, Interleukin-6, tumour necrosis factor-α, muscle strength, exercise capacity, fat-free mass or hospital anxiety.

conclusionImplementation of early physical rehabilitation can improve self-reported physical function and induce systemic anti-inflammatory effects.

Indexed as

Physical FitnessAdultAgedAged, 80 and overAnti-Inflammatory AgentsCritical CareCritical IllnessFemaleHumansMaleMiddle AgedPhysical Therapy ModalitiesPilot ProjectsProspective StudiesQuality of LifeSystemic Inflammatory Response SyndromeAnti-Inflammatory Agents

Identifiers

PMID25851383
OpenAlexW2066161830

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.