Trial reportDiabetologia2015
The impact of lifestyle intervention on sedentary time in individuals at high risk of diabetes.
Trial report in Diabetologia, 2015. The graph read 1 number from its abstract, feeding 1 cell of the map, but it casts no vote: the report of the main result of NCT00004992 is not on the map. It reports registered trial NCT00004992. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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Combining all participants together, there was a significantly increased risk of developing diabetes with increased television watching (3.4% per hour spent watching television), after controlling for age, sex, treatment arm and leisure physical activity (p < 0.01), which was attenuated when time-dependent weight was added to the model.
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Where it lands on the map
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What it adds to each cell
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Diet, exercise & lifestyle×quality of life & behaviour
No readable resultOpen on the map →What to test next →No other readable study in this cell yet. This paper is the evidence.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diabetes Prevention Program
Open the trial in the graphWho cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of behavioral intervention programs for preventing and managing diabetes in adults: a systematic review of evidence.BMC public health · 2025Pooled it
- Interventions outside the workplace for reducing sedentary behaviour in adults under 60 years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Activity and Sedentary Time 10 Years After a Successful Lifestyle Intervention: The Diabetes Prevention Program.American journal of preventive medicine · 2017Trial
- Global risk factors, epidemiology, and disease burden of type 2 diabetes.Science China. Life sciences · 2026Review
- Relationship Between Physical Activity Levels and Type 2 Diabetes in Adults: Zahedan Adult Cohort Study, Iran.Health science reports · 2025Article
- Differences in Associated Factors of Sedentary Behavior by Diabetes Mellitus Status: A Nationwide Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Prevalence of Diabetes in Nepali-Speaking Bhutanese Americans Living in the Greater Harrisburg Area.Cureus · 2023Article
- Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2023Review
- Associations Between Serum Folate Level and HOMA-IR in Chinese Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Effectiveness of a type 2 diabetes prevention program combining FINDRISC scoring and telephone-based coaching in the French population of bakery/pastry employees.European journal of clinical nutrition · 2020Article
- Associations between change in sedentary behavior and outcome in standard behavioral weight loss treatment.Translational behavioral medicine · 2018Article
- Prolonged Screen Viewing Times and Sociodemographic Factors among Pregnant Women: A Cross-Sectional Survey in China.International journal of environmental research and public health · 2018Article
- Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.Nature reviews. Endocrinology · 2018 · on this mapReview
- Association between diabetes and pesticides: a case-control study among Thai farmers.Environmental health and preventive medicine · 2018Article
- Prevalence and Determinants of Gestational Diabetes Mellitus: A Cross-Sectional Study in China.International journal of environmental research and public health · 2017Article
- Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes.BMC medicine · 2017Review
- Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients.Frontiers in physiology · 2017Article
- Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA).BMJ open diabetes research & care · 2016Article
- Lifestyle and the Prevention of Type 2 Diabetes: A Status Report.American journal of lifestyle medicineReview
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14 authors.
Funding
Abstract
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aims/hypothesisThe Diabetes Prevention Program (DPP) lifestyle intervention successfully achieved its goal of increasing leisure physical activity levels. This current study examines whether the lifestyle intervention also changed time spent being sedentary and the impact of sedentary time on diabetes development in this cohort.
methods3,232 DPP participants provided baseline data. Sedentary behaviour was assessed via an interviewer-administered questionnaire and reported as time spent watching television specifically (or combined with sitting at work). Mean change in sedentary time was examined using repeated measures ANCOVA. The relationship between sedentary time and diabetes incidence was determined using Cox proportional hazards models.
resultsDuring the DPP follow-up (mean: 3.2 years), sedentary time declined more in the lifestyle than the metformin or placebo participants (p < 0.05). For the lifestyle group, the decrease in reported mean television watching time (22 [95% CI 26, 17] min/day) was greater than in the metformin or placebo groups (p < 0.001). Combining all participants together, there was a significantly increased risk of developing diabetes with increased television watching (3.4% per hour spent watching television), after controlling for age, sex, treatment arm and leisure physical activity (p < 0.01), which was attenuated when time-dependent weight was added to the model. CONCLUSIONS/
interpretationIn the DPP, the lifestyle intervention was effective at reducing sedentary time, which was not a primary goal. In addition, in all treatment arms, individuals with lower levels of sedentary time had a lower risk of developing diabetes. Future lifestyle intervention programmes should emphasise reducing television watching and other sedentary behaviours in addition to increasing physical activity.
trial registrationClinicalTrials.gov NCT00004992.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.