Evidence map›Paper›PMID 25850975›Full record

Trial reportWorld journal of urology2015

The effects of statins on benign prostatic hyperplasia in elderly patients with metabolic syndrome.

Xiangyu Zhang, Xiaofang Zeng, Lini Dong, Xiaokun Zhao, Xiaobing Qu

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Review
  9. Molecular Mechanisms Underlying Chronic and Degenerative Diseases.International journal of molecular sciences · 2023
    Article
  10. Article
  11. The association of statin subgroups with lower urinary tract symptoms following a prostate biopsy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Topic issue: men's health in 2019.World journal of urology · 2019
    Article
  17. Transurethral resection of the prostate with preservation of the bladder neck decreases postoperative retrograde ejaculation.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2019
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiangyu ZhangDepartment of Geriatrics, Second Xiangya Hospital of Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, P.R. China.
Xiaofang ZengDepartment of Geriatrics, Second Xiangya Hospital of Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, P.R. China.
Lini DongDepartment of Geriatrics, Second Xiangya Hospital of Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, P.R. China.
Xiaokun ZhaoDepartment of Urology, Second Xiangya Hospital of Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, P.R. China.
Xiaobing QuDepartment of Geriatrics, Second Xiangya Hospital of Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, P.R. China. quxiaobing1@163.com.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of simvastatin and atorvastatin in elderly male patients with benign prostatic hyperplasia (BPH) accompanied by metabolic syndrome (MetS).

methodsEligible patients aged >60 year with BPH accompanied by MetS were randomly assigned to receive 40 mg of simvastatin daily, 20 mg of atorvastatin daily or placebo (control group) treatment for 12 months. Serum lipids, interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), prostate-specific antigen, prostate volume (PV) and the International Prostate Symptom Score (IPSS) were tested before and after treatment.

resultsThe levels of serum total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol, hs-CRP, IL-6 and IPSS was decreased, serum high-density lipoprotein cholesterol (HDL-C) was increased, and PV was reduced in the patients following treatments with statins. The PV of the patients who received simvastatin were reduced more than those of the patients who received atorvastatin. The decrease in PV was more significant in the obesity patients than in the normal weight patients and in the hyperlipidemia patients than in the normal-lipid patients following the statin interventions. The reduction in PV was positively related to the decreases in the levels of TC and IL-6 and to the increase in the level of HDL-C.

conclusionsSimvastatin and atorvastatin significantly reduced PV, improved lower urinary tract symptoms, and slowed the clinical progression of BPH possibly by lowering cholesterol and anti-inflammatory factors.

Indexed as

AgedAged, 80 and overAge FactorsAtorvastatinCholesterolC-Reactive ProteinHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-6MaleMetabolic SyndromeMiddle AgedProstate-Specific AntigenProstatic HyperplasiaSimvastatinTriglyceridesAtorvastatinCholesterolC-Reactive ProteinHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-6Prostate-Specific AntigenSimvastatinTriglyceridesBenign prostatic hyperplasiaInflammationLipidsMetabolic syndromeStatin

Identifiers

PMID25850975
OpenAlexW1972029761

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.