ReviewThe journal of physiological sciences : JPS2015
Responses of skeletal muscles to gravitational unloading and/or reloading.
Review in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Medial gastrocnemius activation during graded axial hypergravity induced by short-arm human centrifugation.European journal of applied physiology · 2026Article
- Mitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass.Antioxidants (Basel, Switzerland) · 2026Review
- Effect of traction therapy on muscle satellite cell proliferation and differentiation in a rat model of knee stiffness.Stem cell research & therapy · 2024Article
- Article
- Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept.NPJ microgravity · 2024Article
- Identification of mouse soleus muscle proteins altered in response to changes in gravity loading.Scientific reports · 2023Article
- Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation.Integrative medicine research · 2023Article
- Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice.Communications biology · 2023Article
- A Surgical Approach to Hindlimb Suspension: A Mouse Model of Disuse-Induced Atrophy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Single Cell in a Gravity Field.Life (Basel, Switzerland) · 2022Review
- Early Deconditioning of Human Skeletal Muscles and the Effects of a Thigh Cuff Countermeasure.International journal of molecular sciences · 2021Article
- Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice.NPJ microgravity · 2021Article
- Gravitational Influence on Human Living Systems and the Evolution of Species on Earth.Molecules (Basel, Switzerland) · 2021Review
- Optimal Human Functioning Requires Exercise Across the Lifespan: Mobility in a 1g Environment Is Intrinsic to the Integrity of Multiple Biological Systems.Frontiers in physiology · 2020Review
- Cellular Responses of Human Postural Muscle to Dry Immersion.Frontiers in physiology · 2019Review
- Article
- A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog.Frontiers in physiology · 2019Article
- Release of pro-inflammatory cytokines from muscle and bone causes tenocyte death in a novel rotator cuff in vitro explant culture model.Connective tissue research · 2018Article
- Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation.Scientific reports · 2018Article
- Recent Progress in Space Physiology and Aging.Frontiers in physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation of morphological, metabolic, and contractile properties of skeletal muscles to inhibition of antigravity activities by exposure to a microgravity environment or by simulation models, such as chronic bedrest in humans or hindlimb suspension in rodents, has been well reported. Such physiological adaptations are generally detrimental in daily life on earth. Since the development of suitable countermeasure(s) is essential to prevent or inhibit these adaptations, effects of neural, mechanical, and metabolic factors on these properties in both humans and animals were reviewed. Special attention was paid to the roles of the motoneurons (both efferent and afferent neurograms) and electromyogram activities as the neural factors, force development, and/or length of sarcomeres as the mechanical factors and mitochondrial bioenergetics as the metabolic factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.