ReviewNature reviews. Endocrinology2015
Local and systemic effects of the multifaceted epicardial adipose tissue depot.
Review in Nature reviews. Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06557811 (Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction), which is not on this map. Cited by 294 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction: a Randomized and Double-blind Clinical Trial
Who cites it
294 citing papers in PubMed, 2 syntheses or guidelines pooled it, 576 citations in OpenAlex.
- Association of epicardial adipose tissue with the severity and adverse clinical outcomes of COVID-19: A meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Pooled it
- Epicardial adipose tissue in patients with chronic kidney disease: a meta-analysis study and trial sequential analysis.International urology and nephrology · 2020Pooled it
- Epicardial adipose tissue in obesity with heart failure with preserved ejection fraction: Cardiovascular magnetic resonance biomarker study.World journal of cardiology · 2024Trial
- Vigorous-intensity exercise as a modulator of cardiac adipose tissue in women with obesity: a cross-sectional and randomized pilot study.Frontiers in endocrinology · 2023Trial
- EAT Thickness as a Predominant Feature for Evaluating Arterial Stiffness in Patients with Heart Failure with Preserved Ejection Fraction.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Trial
- Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study.Cardiovascular diabetology · 2021 · on this mapTrial
- lncRNA expression profiles and associated ceRNA network analyses in epicardial adipose tissue of patients with coronary artery disease.Scientific reports · 2021Trial
- Prognostic value of epicardial and pericardial adipose tissue in patients with chronic heart failure.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Standardized MRI-Based Quantification of Epicardial Adipose Tissue Volume: Reproducibility and Agreement With Cardiac Computed Tomography.Journal of magnetic resonance imaging : JMRI · 2026Article
- Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability.Current atherosclerosis reports · 2026Review
- Studies on obesity-related atrial fibrillation in the past 20 years: A bibliometric analysis via CiteSpace and VOSviewer.Medicine · 2026Article
- The Effect of Weight Loss and Metabolic Interventions on Recurrence After Atrial Fibrillation Ablation.Journal of clinical medicine · 2026Review
- Epicardial Adipose Tissue Metabolic Changes Associated with Different Intensities Interval Exercise Preconditioning in Myocardial I/R Injury.Applied biochemistry and biotechnology · 2026Article
- Automated Deep Learning Segmentation and Quantification of Epicardial Adipose Tissue from Coronary Computed Tomography Angiography: Validation and Clinical Implications.Journal of imaging informatics in medicine · 2026Article
- The adipose tissue-plaque crosstalk: omics profiling of perivascular adipose tissues for understanding plaque stability.Cardiovascular diabetology · 2026Review
- Synergistic Prognostic Value of Epicardial Fat Volume and Triglyceride-Glucose Index in Heart Failure Patients With Glycemic Dysregulation.Reviews in cardiovascular medicine · 2026Article
- Pericoronary, but Not Epicardial, Cardiac Fat Thickness Is Associated with Sarcopenia in Hospitalized Older Adults.Medicina (Kaunas, Lithuania) · 2026Observational
- Role of adipose tissue in cardiovascular health and diseases.Chinese medical journal · 2026Review
- Selenium Status Is Associated with Inflammation in Epicardial Adipose Tissue in Elderly Patients with Coronary Artery Disease.Antioxidants (Basel, Switzerland) · 2026Article
- A study on the correlation between cardiac magnetic resonance characteristics and myocardial fibrosis in overweight and obese individuals.BMC medical imaging · 2026Article
234 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic effects. This tissue is distinguished from other visceral fat depots by a number of anatomical and metabolic features, such as increased fatty acid metabolism and a unique transcriptome enriched in genes that are associated with inflammation and endothelial function. Epicardial fat and the heart share an unobstructed microcirculation, which suggests these tissues might interact. Under normal physiological conditions, epicardial fat has metabolic, thermogenic (similar to brown fat) and mechanical (cardioprotective) characteristics. Development of pathological conditions might drive the phenotype of epicardial fat such that it becomes harmful to the myocardium and the coronary arteries. The equilibrium between protective and detrimental effects of this tissue is fragile. Expression of the epicardial-fat-specific transcriptome is downregulated in the presence of severe and advanced coronary artery disease. Improved local vascularization, weight loss and targeted medications can restore the protective physiological functions of epicardial fat. Measurements of epicardial fat have several important applications in the clinical setting: accurate measurement of its thickness or volume is correlated with visceral adiposity, coronary artery disease, the metabolic syndrome, fatty liver disease and cardiac changes. On account of this simple clinical assessment, epicardial fat is a reliable marker of cardiovascular risk and an appealing surrogate for assessing the efficacy of drugs that modulate adipose tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.