Evidence map›Paper›PMID 25850619›Full record

ReviewBiological psychiatry2015

Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.

Benjamin R Pittman-Polletta, Bernat Kocsis, Sujith Vijayan, Miles A Whittington, Nancy J Kopell

Abstract readReview
In one paragraph

Review in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  19. Posterior Parietal Cortex Dysfunction Is Central to Working Memory Storage and Broad Cognitive Deficits in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin R Pittman-PollettaCognitive Rhythms Collaborative , Boston University; Department of Mathematics & Statistics, Boston University. Electronic address: benpolletta@gmail.com.
Bernat KocsisCognitive Rhythms Collaborative , Boston University; Department of Psychiatry, Beth Israel Medical Center, Harvard Medical School, Boston, Massachusetts.
Sujith VijayanDepartment of Mathematics & Statistics, Boston University.
Miles A WhittingtonCognitive Rhythms Collaborative , Boston University; Department of Neuroscience, Hull York Medical School, York University, York, United Kingdom.
Nancy J KopellCognitive Rhythms Collaborative , Boston University; Department of Mathematics & Statistics, Boston University.
Boston University · US

Funding

Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1M
Spatiotemporal Network Dynamics in a Rat Model of SchizophreniaR01MH100820 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DING, MINGZHOU, KOCSIS, BERNAT · 2014 to 2018
$2.1M
CRCNS: Gamma Rhythms and Cell AssembliesR01NS067199 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KOPELL, NANCY · 2009 to 2013
$1.7M
NHLBI NIH HHS P01 HL095491NIMH NIH HHS MH100820NIMH NIH HHS R01 MH100820NINDS NIH HHS R01 NS067199NINDS NIH HHS R01NS067199Wellcome Trust 098352
6 · The paper itself

Abstract

In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillations in neuronal activity tie the pathophysiology of schizophrenia to alterations in local processing and large-scale coordination, and these alterations in turn can lead to the cognitive and perceptual disturbances observed in schizophrenia.

Indexed as

Neural InhibitionSchizophrenic PsychologyAnimalsBrainBrain WavesGABAergic NeuronsGenetic Predisposition to DiseaseHumansInterneuronsSchizophreniaBrain rhythmsCognitionFunctional connectivityInhibitory interneuronsSchizophreniaTemporal coding

Identifiers

PMID25850619
PMCPMC4444389
OpenAlexW1989511823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.