ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2016
The Retinal Response to Sinusoidal Electrical Stimulation.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Computational modelling of the suppression of optic nerve fibre.Medical & biological engineering & computing · 2026Article
- Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus.Frontiers in computational neuroscience · 2024Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study.Journal of neural engineering · 2021Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution.Journal of neural engineering · 2021Article
- The impact of synchronous versus asynchronous electrical stimulation in artificial vision.Journal of neural engineering · 2021Review
- The relationship between morphological properties and thresholds to extracellular electric stimulation in α RGCs.Journal of neural engineering · 2020Article
- Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses.Healthcare technology letters · 2020Article
- An update on retinal prostheses.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Review
- Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina.Scientific reports · 2020Article
- Response of Mouse Visual Cortical Neurons to Electric Stimulation of the Retina.Frontiers in neuroscience · 2019Article
- Visual Prosthesis: Interfacing Stimulating Electrodes with Retinal Neurons to Restore Vision.Frontiers in neuroscience · 2017Review
- Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?Annals of translational medicine · 2016Article
- Temporal properties of network-mediated responses to repetitive stimuli are dependent upon retinal ganglion cell type.Journal of neural engineering · 2016Article
- Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.Science translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Rectangular electrical pulses are the primary stimulus waveform used in retinal prosthetics as well as many other neural stimulation applications. Unfortunately, the utility of pulsatile stimuli is limited by the inability to avoid the activation of passing axons, which can result in the distortion of the spatial patterns of elicited neural activity. Because avoiding axons would likely improve clinical outcomes, the examination of alternate stimulus waveforms is warranted. Here, we studied the response of rabbit retinal ganglion cells (RGCs) to sinusoidal electrical stimulation applied at frequencies of 5, 10, 25, and 100 Hz. Targeted RGCs were restricted to 4 common types: OFF-Brisk Transient, OFF-Sustained, ON-Brisk Transient, and ON-Sustained. Interestingly, response patterns varied between different types; the most notable difference was the relatively weak response of ON-Sustained cells to low frequencies. Calculation of total spike counts per trial revealed that lower frequencies are more charge efficient than high frequencies. Finally, experiments utilizing synaptic blockers revealed that 5 and 10 Hz activate photoreceptors while 25 and 100 Hz activate RGCs. Taken together, our results suggest that while sinusoidal electrical stimulation may provide a useful research tool, its clinical utility may be limited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.