ArticleNature neuroscience2015
Neuronal activity biases axon selection for myelination in vivo.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 280 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
280 citing papers in PubMed, 440 citations in OpenAlex.
- Volume electron microscopy reveals oligodendrocyte axon selection patterns and spatial assembly of myelin and nodes.iScience · 2026Article
- Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy.Acta neuropathologica communications · 2026Article
- M2-associated microglial states in oligodendrocyte regulation and white matter repair in vascular dementia.Journal of translational medicine · 2026Review
- Myelin sheath lengths in the central nervous system scale to axon diameter via oligodendroglial Piezo1.PLoS biology · 2026Article
- Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology.Developmental cell · 2026Article
- Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth.Nature communications · 2026Article
- Cortical and white matter myelination proceed in concert during early infancy.Nature communications · 2026Article
- Multiple adhesion molecules act together in oligodendrocyte-mediated axonal selection and myelin formation.PLoS biology · 2026Article
- RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish.PLoS genetics · 2026Article
- Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum.Glia · 2026Article
- Article
- Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndrome.bioRxiv : the preprint server for biology · 2026Article
- PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential.bioRxiv : the preprint server for biology · 2026Article
- Tunable hydrogel-based micropillar arrays for myelination studies.Nature methods · 2026Article
- Article
- Fiber Track Length Gradients in the Avian Sound Localization Circuit Require Conduction Velocity Gradients to Maintain Isochronicity.The Journal of comparative neurology · 2026Article
- The regenerative period of somatosensory nerves is closed by a DCC signaling axis.PLoS genetics · 2026Article
- Two axes of white matter development.Nature communications · 2026Article
- Mechanobiology of Myelin Generation/Regeneration in Health and Disease.Results and problems in cell differentiation · 2026Review
- From synapse to sheath: how OPCs couple neural activity to adaptive myelination and behavioral plasticity.Frontiers in cell and developmental biology · 2026Review
220 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
An essential feature of vertebrate neural development is ensheathment of axons with myelin, an insulating membrane formed by oligodendrocytes. Not all axons are myelinated, but mechanisms directing myelination of specific axons are unknown. Using zebrafish, we found that activity-dependent secretion stabilized myelin sheath formation on select axons. When VAMP2-dependent exocytosis was silenced in single axons, oligodendrocytes preferentially ensheathed neighboring axons. Nascent sheaths formed on silenced axons were shorter in length, but when activity of neighboring axons was also suppressed, inhibition of sheath growth was relieved. Using in vivo time-lapse microscopy, we found that only 25% of oligodendrocyte processes that initiated axon wrapping were stabilized during normal development and that initiation did not require activity. Instead, oligodendrocyte processes wrapping silenced axons retracted more frequently. We propose that axon selection for myelination results from excessive and indiscriminate initiation of wrapping followed by refinement that is biased by activity-dependent secretion from axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.