ArticlePloS one2015
Mitogen-activated protein kinases are associated with the regulation of physiological traits and virulence in Fusarium oxysporum f. sp. cubense.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Genome-Wide Analysis ofJournal of fungi (Basel, Switzerland) · 2026Article
- Triamcinolone Acetonide Produced by Bacillus velezensis YEBBR6 Exerts Antagonistic Activity Against Fusarium oxysporum f. sp. Cubense: A Computational Analysis.Molecular biotechnology · 2026Article
- Host-Induced Silencing of Rhizoctonia Solani 5-Enolpyruvylshikimate-3-Phosphate Synthase Impairs Its Virulence in Rice.Plant biotechnology journal · 2026Article
- Histidinol-Phosphate Phosphatase FoHis2 Is Essential for Growth, Stress Responses, and Full Virulence inJournal of fungi (Basel, Switzerland) · 2026Article
- Enhancing soil citrulline degrading function to mitigate soil-borne Fusarium wilt.Nature communications · 2026Article
- Patho-Ecological Distribution and Genetic Diversity ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Ubiquitous Wilt-Inducing PathogenPathogens (Basel, Switzerland) · 2024Review
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- Insights on mining the pangenome ofFrontiers in microbiology · 2024Article
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- Molecular, Histological and Histochemical Responses of Banana Cultivars Challenged withPlants (Basel, Switzerland) · 2022Article
- FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by silencing a glycosyl hydrolase coding gene expression.PLoS pathogens · 2022Article
- Comparative genome analyses suggest a hemibiotrophic lifestyle and virulence differences for the beech bark disease fungal pathogens Neonectria faginata and Neonectria coccinea.G3 (Bethesda, Md.) · 2021Article
- Article
- An Exo-Polygalacturonase Pgc4 Regulates Aerial Hyphal Growth and Virulence inInternational journal of molecular sciences · 2020Article
- Predicting Virulence ofToxins · 2020Article
- Transcriptomic analyses revealed the effect of Funneliformis mosseae on genes expression in Fusarium oxysporum.PloS one · 2020Article
- TheFrontiers in genetics · 2020Article
- Fusarium oxysporum f. sp. lycopersici CCurrent genetics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium oxysporum f. sp. cubense (FOC) is an important soil-borne fungal pathogen causing devastating vascular wilt disease of banana plants and has become a great concern threatening banana production worldwide. However, little information is known about the molecular mechanisms that govern the expression of virulence determinants of this important fungal pathogen. In this study, we showed that null mutation of three mitogen-activated protein (MAP) kinase genes, designated as FoSlt2, FoMkk2 and FoBck1, respectively, led to substantial attenuation in fungal virulence on banana plants. Transcriptional analysis revealed that the MAP kinase signaling pathway plays a key role in regulation of the genes encoding production of chitin, peroxidase, beauvericin and fusaric acid. Biochemical analysis further confirmed the essential role of MAP kinases in modulating the production of fusaric acid, which was a crucial phytotoxin in accelerating development of Fusarium wilt symptoms in banana plants. Additionally, we found that the MAP kinase FoSlt2 was required for siderophore biosynthesis under iron-depletion conditions. Moreover, disruption of the MAP kinase genes resulted in abnormal hypha and increased sensitivity to Congo Red, Calcofluor White and H2O2. Taken together, these results depict the critical roles of MAP kinases in regulation of FOC physiology and virulence.
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