Evidence map›Paper›PMID 25849835›Full record

ArticleAIDS (London, England)2015

High HIV prevalence and incidence among MSM across 12 cities in India.

Sunil S Solomon, Shruti H Mehta, Aylur K Srikrishnan, Canjeevaram K Vasudevan, Allison M Mcfall, Pachamuthu Balakrishnan, Santhanam Anand, Panneerselvam Nandagopal, Elizabeth L Ogburn, Oliver Laeyendecker and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01686750 (A Cluster Randomized Trial of Integrated Care Centers to Improve Access to HIV Prevention, Testing, and Treatment Services Among High-Risk Vulnerable Populations in India), which is not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01686750 nacompletednot on this map

A Cluster Randomized Trial of Integrated Care Centers to Improve Access to HIV Prevention, Testing, and Treatment Services Among High-Risk Vulnerable Populations in India

TypeinterventionalSponsorJohns Hopkins UniversityRan2012 to 2017Enrolled21,726ConditionsHIV InfectionArmsIntegrated care centers
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Circumcision for HIV Prevention in Men Who Have Sex With Men: An Updated Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2026
    Pooled it
  2. Pooled it
  3. Community viral load and hepatitis C virus infection: Community viral load measures to aid public health treatment efforts and program evaluation.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Pooled it
  4. Pooled it
  5. Bias Adjustment Techniques Are Underutilized in HIV Sexual Risk Estimation: A Systematic Review.International journal of environmental research and public health · 2018
    Pooled it
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  14. HIV care continuum among men who have sex with men and persons who inject drugs in India: barriers to successful engagement.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Trial
  15. Article
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  17. Establishing HIV transmission pathways in Bhutan: a modelling study.The Lancet regional health. Southeast Asia · 2025
    Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Sunil S SolomonaDepartment of Medicine, Johns Hopkins School of Medicine bDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA cYR Gaitonde Centre for AIDS Research and Education, Chennai, India dNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Shruti H Mehta
Aylur K Srikrishnan
Canjeevaram K Vasudevan
Allison M Mcfall
Pachamuthu Balakrishnan
Santhanam Anand
Panneerselvam Nandagopal
Elizabeth L Ogburn
Oliver Laeyendecker
Gregory M Lucas
Suniti Solomon
David D Celentano
YR Gaitonde Centre for AIDS Research and Education · INJohns Hopkins University · USNational Institute of Allergy and Infectious Diseases · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Laboratory and Statistical Development of Cross-Sectional HIV Incidence AssaysR01AI095068 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ESHLEMAN, SUSAN H · 2011 to 2021
$6.6M
Integrated Care Clinics for IDUs in India: a cluster randomized trialR01DA032059 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M, MEHTA, SHRUTI H · 2011 to 2015
$6.3M
Preventing HIV Infection Among MSM in Southern IndiaR01MH089266 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CELENTANO, DAVID D. · 2010 to 2015
$2.9M
Treatment outcomes and comorbidity in HIV-infected IDUK24DA035684 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2014 to 2024
$1.5M
Intramural NIH HHSNIAID NIH HHS 1P30AI094189NIAID NIH HHS AI095068NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI095068NIDA NIH HHS DA 032059NIDA NIH HHS DA035684NIDA NIH HHS K24 DA035684NIDA NIH HHS R01 DA032059NIMH NIH HHS MH 89266NIMH NIH HHS R01 MH089266
6 · The paper itself

Abstract

objectiveTo characterize prevalence, incidence, and associated correlates of HIV infection among MSM in 12 cities across India.

designCross-sectional sample using respondent-driven sampling from September 2012 to June 2013.

methodsA total 12022 MSM (~1000/city) were recruited. Participants had to be at least 18 years, self-identify as male, and report oral/anal intercourse with a man in the prior year. HIV infection was diagnosed using three rapid tests. Cross-sectional HIV incidence was estimated using a multiassay algorithm. All estimates incorporate respondent-driven sampling-II weights.

resultsMedian age was 25 years, 45% self-identified as 'panthi' (predominantly penetrative anal intercourse) and 30.6% reported being married to a woman. Weighted HIV prevalence was 7.0% (range: 1.7-13.1%). In multivariate analysis, significantly higher odds of HIV infection was observed among those who were older, had lower educational attainment, were practicing purely receptive anal sex or both receptive and penetrative sex, and those who were herpes simplex virus-2 positive. Of 1147 MSM who tested HIV positive, 53 were identified as recent HIV infections (annualized incidence = 0.87%; range = 0-2.2%). In multivariate analysis, injecting drugs in the prior 6 months, syphilis, and higher number of male partners and fewer female partners were significantly associated with recent HIV infection.

conclusionWe observed a high burden of HIV among MSM in India with tremendous diversity in prevalence, incidence, and risk behaviors. In particular, we observed high incidence in areas with relatively low prevalence suggesting emerging epidemics in areas not previously recognized to have high HIV burden.

Indexed as

Homosexuality, MaleAdolescentAdultCitiesCross-Sectional StudiesHIV InfectionsHumansIncidenceIndiaMaleMiddle AgedPrevalenceRisk-TakingUrban PopulationYoung Adult

Identifiers

PMID25849835
PMCPMC4440484
OpenAlexW2073995266

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.