Observational studyPloS one2015
Assessment of brainstem function with auricular branch of vagus nerve stimulation in Parkinson's disease.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression.Translational psychiatry · 2025Trial
- Non-Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load.Psychophysiology · 2025Trial
- Trial
- The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people.PloS one · 2022Trial
- Functional near-infrared spectroscopy and vagus somatosensory evoked potentials add to the power of established parameters such as poor cognitive performance, dsyosmia and APOe genotype to predict cognitive decline over 8 years in the elderly.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Vagus nerve stimulation in Parkinson's disease: a scoping review of animal studies and human subjects research.NPJ Parkinson's disease · 2024Article
- Brain Networks Involved in Sensory Perception in Parkinson's Disease: A Scoping Review.Brain sciences · 2023Article
- Article
- Article
- Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study.International journal of environmental research and public health · 2021Article
- Heart Rate Variability Analyses in Parkinson's Disease: A Systematic Review and Meta-Analysis.Brain sciences · 2021Review
- International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).Frontiers in human neuroscience · 2020Review
- Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice.Frontiers in neuroscience · 2020Review
- Anatomo-Physiologic Basis for Auricular Stimulation.Medical acupuncture · 2018Review
- Cervical vagus nerve morphometry and vascularity in the context of nerve stimulation - A cadaveric study.Scientific reports · 2018Article
- Axonal Degeneration of the Vagus Nerve in Parkinson's Disease-A High-Resolution Ultrasound Study.Frontiers in neurology · 2018Article
- Atrophy of the Vagus Nerve in Parkinson's Disease Revealed by High-Resolution Ultrasonography.Frontiers in neurology · 2018Article
- Innervation of the Human Cavum Conchae and Auditory Canal: Anatomical Basis for Transcutaneous Auricular Nerve Stimulation.BioMed research international · 2017Article
- It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias.Heart rhythm · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe efferent dorsal motor nucleus of the vagal nuclei complex may degenerate early in the course of Parkinson's disease (PD), while efferent nucleus ambiguous, the principal source of parasympathetic vagal neurons innervating the heart, and afferent somatosensory nuclei remain intact.
objectiveTo obtain neurophysiological evidence related to this pattern, we tested processing of afferent sensory information transmitted via the auricular branch of the vagus nerve (ABVN) which is known to be connected to autonomic regulation of cardiac rhythm.
methodsIn this cross-sectional observational study, we recorded (i) somatosensory evoked potentials (ABVN-SEP) and (ii) cutaneo-cardioautonomic response elicited by stimulation of the ABVN (modulation of heart-rate variability (HRV index; low frequency power, ln(LF), high frequency power, ln(HF); ln(LF/HF) ratio)) in 50 PD patients and 50 age and sex matched healthy controls. Additionally, auditory evoked potentials and trigeminal nerve SEP were assessed.
resultsNeither ABVN-SEP nor any of the other functional brainstem parameters differed between patients and controls. Although HRV index was decreased in PD patients, modulation of ln(LF/HF) by ABVN-stimulation, likely indicating cardiac parasympathetic activation, did not differ between both groups.
conclusionsFindings do not point to prominent dysfunction of processing afferent information from ABVN and its connected parasympathetic cardiac pathway in PD. They are consistent with the known pattern of degeneration of the vagal nuclei complex of the brainstem.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.