Evidence map›Paper›PMID 25849778›Full record

ArticlePloS one2015

Predictive value of S100-B and copeptin for outcomes following seizure: the BISTRO International Cohort Study.

Yonathan Freund, Benjamin Bloom, Jerome Bokobza, Nacera Baarir, Said Laribi, Tim Harris, Vincent Navarro, Maguy Bernard, Rupert Pearse, Bruno Riou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Pathophysiology of Status Epilepticus Revisited.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yonathan FreundSorbonne universités, UPMC Univ Paris 06, UMRS INSERM 1166, IHU ICAN, Paris, France; Emergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Benjamin BloomEmergency Department, Royal London Hospital, London, United Kingdom; Queen Mary University of London, London, United Kingdom.
Jerome BokobzaEmergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Nacera BaarirEmergency Department, Hôpital Tenon, APHP, Paris, France.
Said LaribiEmergency Department, Hôpital Lariboisière, APHP, Paris, France.
Tim HarrisEmergency Department, Royal London Hospital, London, United Kingdom; Queen Mary University of London, London, United Kingdom.
Vincent NavarroNeurology Department, Hôpital Pitié-Salpêtrière, APHP, Paris, France.
Maguy BernardBiochemistry Department, Hôpital Pitié-Salpêtrière, APHP, Paris, France; Université Paris 5 Paris Cité, Paris, France.
Rupert PearseAdult critical care unit, Royal London Hospital, London, United Kingdom; Queen Mary University of London, London, United Kingdom.
Bruno RiouSorbonne universités, UPMC Univ Paris 06, UMRS INSERM 1166, IHU ICAN, Paris, France; Emergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Pierre HausfaterSorbonne universités, UPMC Univ Paris 06, UMRS INSERM 1166, IHU ICAN, Paris, France; Emergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
BISTRO Investigators
Sorbonne Université · FRQueen Mary University of London · GBAssistance Publique – Hôpitaux de Paris · FRUnité de recherche sur les maladies cardiovasculaires et métaboliques · FR

Funding

Department of Health CS/08/08/17Department of Health RP_2014-04-022
6 · The paper itself

Abstract

objectiveTo evaluate the performance of S100-B protein and copeptin, in addition to clinical variables, in predicting outcomes of patients attending the emergency department (ED) following a seizure.

methodsWe prospectively included adult patients presented with an acute seizure, in four EDs in France and the United Kingdom. Participants were followed up for 28 days. The primary endpoint was a composite of seizure recurrence, all-cause mortality, hospitalization or rehospitalisation, or return visit in the ED within seven days.

resultsAmong the 389 participants included in the analysis, 156 (40%) experienced the primary endpoint within seven days and 195 (54%) at 28 days. Mean levels of both S100-B (0.11 μg/l [95% CI 0.07-0.20] vs 0.09 μg/l [0.07-0.14]) and copeptin (23 pmol/l [9-104] vs 17 pmol/l [8-43]) were higher in participants meeting the primary endpoint. However, both biomarkers were poorly predictive of the primary outcome with a respective area under the receiving operator characteristic curve of 0.57 [0.51-0.64] and 0.59 [0.54-0.64]. Multivariable logistic regression analysis identified higher age (odds ratio [OR] 1.3 per decade [1.1-1.5]), provoked seizure (OR 4.93 [2.5-9.8]), complex partial seizure (OR 4.09 [1.8-9.1]) and first seizure (OR 1.83 [1.1-3.0]) as independent predictors of the primary outcome. A second regression analysis including the biomarkers showed no additional predictive benefit (S100-B OR 3.89 [0.80-18.9] copeptin OR 1 [1.00-1.00]).

conclusionThe plasma biomarkers S100-B and copeptin did not improve prediction of poor outcome following seizure. Higher age, a first seizure, a provoked seizure and a partial complex seizure are independently associated with adverse outcomes.

Indexed as

AdultCohort StudiesEmergency Service, HospitalEndpoint DeterminationFemaleGlycopeptidesHospitalizationHumansInternationalityMalePredictive Value of TestsPrognosisRecurrenceS100 Calcium Binding Protein beta SubunitSeizurescopeptinsGlycopeptidesS100 Calcium Binding Protein beta Subunit

Identifiers

PMID25849778
PMCPMC4388444
OpenAlexW2087335772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.