Evidence map›Paper›PMID 25849740›Full record

ArticleImmunology and cell biology2015

Lpr-induced systemic autoimmunity is unaffected by mast cell deficiency.

Annemarie Em van Nieuwenhuijze, Bénédicte Cauwe, Denise Klatt, Stéphanie Humblet-Baron, Adrian Liston

Abstract read
PubMed Publisher
In one paragraph

Article in Immunology and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Annemarie Em van NieuwenhuijzeAutoimmune Genetics Laboratory, VIB, Leuven, Belgium.
Bénédicte CauweAutoimmune Genetics Laboratory, VIB, Leuven, Belgium.
Denise KlattAutoimmune Genetics Laboratory, VIB, Leuven, Belgium.
Stéphanie Humblet-BaronAutoimmune Genetics Laboratory, VIB, Leuven, Belgium.
Adrian ListonAutoimmune Genetics Laboratory, VIB, Leuven, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of mast cells in allergic and organ-specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of mast cells in systemic autoimmunity in the B6(lpr/lpr) mouse, a spontaneous model of systemic lupus erythematosus. B6(lpr/lpr) mice were interbred with C57Bl/6-Kit(W-sh/W-sh) (Wsh) mice, resulting in mast cell deficiency. The offspring from this cross (Lpr/Wsh mice) developed symptoms of lupus of the same severity as B6(lpr/lpr) mice. Loss of mast cells on the Lpr background did not alter autoantibody production, proteinuria, the composition of T and B cell populations or autoimmune pathology. Reduced c-Kit expression did drive expanded splenomegaly and impeded interleukin-4 production by CD4(+) cells, suggesting minor functions for mast cells. In general, we conclude that mast cell deficiency and c-Kit deficiency do not play a role in the pathogenesis of lupus in B6(lpr/lpr) mice.

Indexed as

AnimalsAutoantibodiesAutoimmunityCD4-Positive T-LymphocytesDisease Models, AnimalHumansInterleukin-4Lupus Erythematosus, SystemicMast CellsMiceMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutProto-Oncogene Proteins c-kitAutoantibodiesInterleukin-4Proto-Oncogene Proteins c-kit

Identifiers

PMID25849740
OpenAlexW1980999397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.