ArticleInternational journal of molecular sciences2015
SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 89 citations in OpenAlex.
- Integrating Structures and Biology: Cellular and Molecular Interactions with Functionally Graded Spinal Cage Designs.International journal of molecular sciences · 2026Review
- Fabrication of Superhydrophobic Micro-Nanostructures on Pristine SLM-Ti Surfaces.Micromachines · 2026Article
- Surface modifications of titanium dental implants: optimizing antibacterial activity and osteoimmunomodulation.Frontiers in bioengineering and biotechnology · 2026Review
- AI-Assisted Design and Evaluation of SLM-Ti64 Implants for Enhanced Bone Regeneration.Advanced healthcare materials · 2025Article
- HMGB1 as an emerging key modulator of bone remodeling: a narrative review.Stem cell research & therapy · 2025Review
- Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects: Reconstruction, anti-infection, and osseointegration.Bioactive materials · 2024Article
- Parametric Design of Porous Structure and Optimal Porosity Gradient Distribution Based on Root-Shaped Implants.Materials (Basel, Switzerland) · 2024Article
- Porous metal implants: processing, properties, and challenges.International journal of extreme manufacturing · 2023Review
- Improving Biocompatibility for Next Generation of Metallic Implants.Progress in materials science · 2023Article
- A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections.Materials today. Bio · 2022Article
- Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.Biomedical materials (Bristol, England) · 2022Review
- Mandibular Body Reconstruction Utilizing a Three-Dimensional Custom-Made Porous Titanium Plate: A Four-Year Follow-Up Clinical Report.Case reports in dentistry · 2022Article
- Nanostructured Zn-Substituted Monetite Based Material Induces Higher Bone Regeneration Than Anorganic Bovine Bone and β-Tricalcium Phosphate in Vertical Augmentation Model in Rabbit Calvaria.Nanomaterials (Basel, Switzerland) · 2021Article
- Tunable, Anisotropic Permeability and Spatial Flow of SLM Manufactured Structures.Materials (Basel, Switzerland) · 2021Article
- 3D Printing Technologies in Metallic Implants: A Thematic Review on the Techniques and Procedures.International journal of bioprinting · 2021Review
- Porous Tantalum VS. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation.Journal of clinical medicine · 2020Article
- Extrusion and Microfluidic-based Bioprinting to Fabricate Biomimetic Tissues and Organs.Advanced materials technologies · 2020Article
- Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019Review
- Bioprinting in Vascularization StrategiesIranian biomedical journal · 2019Review
- Bio-Functional Design, Application and Trends in Metallic Biomaterials.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To improve well-known titanium implants, pores can be used for increasing bone formation and close bone-implant interface. Selective Laser Melting (SLM) enables the production of any geometry and was used for implant production with 250-µm pore size. The used pore size supports vessel ingrowth, as bone formation is strongly dependent on fast vascularization. Additionally, proangiogenic factors promote implant vascularization. To functionalize the titanium with proangiogenic factors, polycaprolactone (PCL) coating can be used. The following proangiogenic factors were examined: vascular endothelial growth factor (VEGF), high mobility group box 1 (HMGB1) and chemokine (C-X-C motif) ligand 12 (CXCL12). As different surfaces lead to different cell reactions, titanium and PCL coating were compared. The growing into the porous titanium structure of primary osteoblasts was examined by cross sections. Primary osteoblasts seeded on the different surfaces were compared using Live Cell Imaging (LCI). Cross sections showed cells had proliferated, but not migrated after seven days. Although the cell count was lower on titanium PCL implants in LCI, the cell count and cell spreading area development showed promising results for titanium PCL implants. HMGB1 showed the highest migration capacity for stimulating the endothelial cell line. Future perspective would be the incorporation of HMGB1 into PCL polymer for the realization of a slow factor release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.