ArticlePloS one2015
An ANNEXIN-like protein from the cereal cyst nematode Heterodera avenae suppresses plant defense.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 62 citations in OpenAlex.
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- The woody plant-degrading pathogen Lasiodiplodia theobromae effector LtCre1 targets the grapevine sugar-signaling protein VvRHIP1 to suppress host immunity.Journal of experimental botany · 2023Article
- EssentialInternational journal of molecular sciences · 2022Article
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- A Putative Effector LtCSEP1 fromPlants (Basel, Switzerland) · 2022Article
- Characterization of FiveInternational journal of molecular sciences · 2022Article
- A bZIP transcription factor, PqbZIP1, is involved in the plant defense response of American ginseng.PeerJ · 2022Article
- Spray-induced gene silencing for disease control is dependent on the efficiency of pathogen RNA uptake.Plant biotechnology journal · 2021Article
- A Venom Allergen-Like Protein, RsVAP, the First Discovered Effector Protein ofInternational journal of molecular sciences · 2021Article
- Identification and Functional Analysis of AopN, anInternational journal of molecular sciences · 2020Article
- The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita.BMC plant biology · 2020Article
- Article
- A MIF-like effector suppresses plant immunity and facilitates nematode parasitism by interacting with plant annexins.Journal of experimental botany · 2019Article
- The potato cyst nematode effector RHA1B is a ubiquitin ligase and uses two distinct mechanisms to suppress plant immune signaling.PLoS pathogens · 2019Article
- Two venom allergen-like proteins, HaVAP1 and HaVAP2, are involved in the parasitism of Heterodera avenae.Molecular plant pathology · 2019Article
- Resistance to Cereal Cyst Nematodes in Wheat and Barley: An Emphasis on Classical and Modern Approaches.International journal of molecular sciences · 2019Review
- Article
- A Novel G16B09-Like Effector FromFrontiers in plant science · 2019Article
- RNAi-Based Biocontrol of Wheat Nematodes Using Natural Poly-Component Biostimulants.Frontiers in plant science · 2019Article
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasitism genes encoding secreted effector proteins of plant-parasitic nematodes play important roles in facilitating parasitism. An annexin-like gene was isolated from the cereal cyst nematode Heterodera avenae (termed Ha-annexin) and had high similarity to annexin 2, which encodes a secreted protein of Globodera pallida. Ha-annexin encodes a predicted 326 amino acid protein containing four conserved annexin domains. Southern blotting revealed that there are at least two homologies in the H. avenae genome. Ha-annexin transcripts were expressed within the subventral gland cells of the pre-parasitic second-stage juveniles by in situ hybridization. Additionally, expression of these transcripts were relatively higher in the parasitic second-stage juveniles by quantitative real-time RT-PCR analysis, coinciding with the time when feeding cell formation is initiated. Knockdown of Ha-annexin by method of barley stripe mosaic virus-based host-induced gene silencing (BSMV-HIGS) caused impaired nematode infections at 7 dpi and reduced females at 40 dpi, indicating important roles of the gene in parasitism at least in early stage in vivo. Transiently expression of Ha-ANNEXIN in onion epidermal cells and Nicotiana benthamiana leaf cells showed the whole cell-localization. Using transient expression assays in N. benthamiana, we found that Ha-ANNEXIN could suppress programmed cell death triggered by the pro-apoptotic mouse protein BAX and the induction of marker genes of PAMP-triggered immunity (PTI) in N. benthamiana. In addition, Ha-ANNEXIN targeted a point in the mitogen-activated protein kinase (MAPK) signaling pathway downstream of two kinases MKK1 and NPK1 in N. benthamiana.
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