Evidence map›Paper›PMID 25849520›Full record

Observational studyAmerican journal of ophthalmology2015

Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.

Jane Z Kuo, Linda M Zangwill, Felipe A Medeiros, Jeffery M Liebmann, Christopher A Girkin, Na'ama Hammel, Jerome I Rotter, Robert N Weinreb

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  9. Journal of ophthalmology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jane Z KuoHamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California; Pathway Genomics Corporation, San Diego, California.
Linda M ZangwillHamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California.
Felipe A MedeirosHamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California.
Jeffery M LiebmannHarkness Eye Institute, Columbia University Medical Center, New York, New York.
Christopher A GirkinDepartment of Ophthalmology, University of Alabama, Callahan Eye Hospital, Birmingham, Alabama.
Na'ama HammelHamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California.
Robert N WeinrebHamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California. Electronic address: rweinreb@ucsd.edu.
University of California, San Diego · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham Hospital · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
xADAGES III: Contribution of genotype to glaucoma phenotype in African AmericansR01EY023704 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROTTER, JEROME I, WEINREB, ROBERT N · 2013 to 2017
$6.3M
VISUAL FUNCTION IN GLAUCOMA AND OCULAR HYPERTENSIONR01EY008208 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 1990 to 2010
$5.7M
Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
Quantification of Glaucomatous Optic NeuropathyK23EY013959 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GIRKIN, CHRISTOPHER ANTHONY · 2002 to 2006
$994k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NEI NIH HHS EY019869NEI NIH HHS EY021818NEI NIH HHS EY023704NEI NIH HHS EY08208NEI NIH HHS EY11008NEI NIH HHS EY13959NEI NIH HHS K23 EY013959NEI NIH HHS P30 EY022589NEI NIH HHS P30EY022589NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY021818NEI NIH HHS R01 EY023704NEI NIH HHS U10 EY014267NEI NIH HHS U10EY14267NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

purposeTo perform a quantitative trait locus (QTL) analysis and evaluate whether a locus between SIX1 and SIX6 is associated with retinal nerve fiber layer (RNFL) thickness in individuals of European descent.

designObservational, multicenter, cross-sectional study.

methodsA total of 231 participants were recruited from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. Association of rs10483727 in SIX1-SIX6 with global and sectoral RNFL thickness was performed. Quantitative trait analysis with the additive model of inheritance was analyzed using linear regression. Trend analysis was performed to evaluate the mean global and sectoral RNFL thickness with 3 genotypes of interest (T/T, C/T, C/C). All models were adjusted for age and sex.

resultsDirection of association between T allele and RNFL thickness was consistent in the global and different sectoral RNFL regions. Each copy of the T risk allele in rs10483727 was associated with -0.16 μm thinner global RNFL thickness (β = -0.16, 95% confidence interval: -0.28 to -0.03; P = .01). Similar patterns were found for the sectoral regions, including inferior (P = .03), inferior-nasal (P = .017), superior-nasal (P = .0025), superior (P = .002) and superior-temporal (P = .008). The greatest differences were observed in the superior and inferior quadrants, supporting clinical observations for RNFL thinning in glaucoma. Thinner global RNFL was found in subjects with T/T genotypes compared to subjects with C/T and C/C genotypes (P = .044).

conclusionsEach copy of the T risk allele has an additive effect and was associated with thinner global and sectoral RNFL. Findings from this QTL analysis further support a genetic contribution to glaucoma pathophysiology.

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociAgedCross-Sectional StudiesEye ProteinsFemaleGenotyping TechniquesGlaucoma, Open-AngleHomeobox Protein SIX3Homeodomain ProteinsHumansMaleMiddle AgedNerve FibersNerve Tissue ProteinsRetinal Ganglion CellsEye ProteinsHomeobox Protein SIX3Homeodomain ProteinsNerve Tissue ProteinsSIX1 protein, humanSIX2 protein, humanSIX4 protein, humanSIX5 protein, humanSIX6 protein, humanTrans-Activators

Identifiers

PMID25849520
PMCPMC4509729
OpenAlexW2138767233

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.