Evidence map›Paper›PMID 25849473›Full record

ReviewAnesthesia progress2015

Alpha-2 adrenergic receptor agonists: a review of current clinical applications.

Joseph A Giovannitti, Sean M Thoms, James J Crawford

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesia progress, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04758936 (Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients), which is not on this map. Cited by 255 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed, 10 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04758936 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.

TypeinterventionalSponsorErasme University HospitalRan2021 to 2023Enrolled50ConditionsDelirium, Critical IllnessArmsClonidine, Dexmedetomidine
3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 10 syntheses or guidelines pooled it, 590 citations in OpenAlex.

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  18. αMolecular psychiatry · 2026
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195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph A GiovannittiProfessor and Chair and.
Sean M Thoms
James J Crawford
University of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The α-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving. (1) However, in more recent years, these drugs have been used as adjuncts for sedation and to reduce anesthetic requirements. This review will provide an historical perspective of this drug class, an understanding of pharmacological mechanisms, and an insight into current applications in clinical anesthesiology.

Indexed as

Anesthesia, DentalProcedural SedationAdjuvants, AnesthesiaAdrenergic alpha-2 Receptor AgonistsAnesthesia, GeneralHumansHypnotics and SedativesAdjuvants, AnesthesiaAdrenergic alpha-2 Receptor AgonistsHypnotics and SedativesAlpha-2 agonistsClonidineDexmedetomidineGeneral anesthesiaProcedural sedation

Identifiers

PMID25849473
PMCPMC4389556
OpenAlexW2101795926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.