ArticlePloS one2015
The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Functional and Evolutionary Insights of NR1J1 Nuclear Receptors: A Diversified Sensing Weapon in Bivalves.International journal of molecular sciences · 2026Article
- Regulation of the amh gene promoter activity by SF-1 in sex-reversing Cheilinus undulatus and its adaptive evolution.BMC genomics · 2026Article
- Understanding Target-Specific Effects of Antidepressant Drug Pollution on Molluscs: A Systematic Review Report.Toxics · 2025Review
- Characterization of NR1J1 Paralog Responses of Marine Mussels: Insights from Toxins and Natural Activators.International journal of molecular sciences · 2024Article
- First characterization of the nuclear receptor superfamily in the Mediterranean musselPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA binding domains (2DBD-NRs).PloS one · 2023Article
- Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol.PloS one · 2023Article
- Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals.Integrated environmental assessment and management · 2023Review
- Common aquatic pollutants modify hemocyte immune responses inFrontiers in immunology · 2022Article
- Review
- Function and Evolution of Nuclear Receptors in Environmental-Dependent Postembryonic Development.Frontiers in cell and developmental biology · 2021Review
- RXR Expression in Marine Gastropods with Different Sensitivity to Imposex Development.Scientific reports · 2020Article
- Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled "banana-shaped" shell.Scientific reports · 2019Article
- Nuclear hormone receptors in parasitic Platyhelminths.Molecular and biochemical parasitology · 2019Review
- Chinese liquor extract enhances inflammation resistance in RAW 264.7 and reduces aging inRSC advances · 2018Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
- Transcriptome analysis of the epidermis of the purple quail-like (q-lp) mutant of silkworm, Bombyx mori.PloS one · 2017Article
- Article
- Dynamics of nuclear receptor gene expression during Pacific oyster development.BMC developmental biology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Nuclear receptors (NRs) are transcription regulators involved in an array of diverse physiological functions including key roles in endocrine and metabolic function. The aim of this study was to identify nuclear receptors in the fully sequenced genome of the gastropod snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni and compare these to known vertebrate NRs, with a view to assessing the snail's potential as a invertebrate model organism for endocrine function, both as a prospective new test organism and to elucidate the fundamental genetic and mechanistic causes of disease. For comparative purposes, the genome of a second gastropod, the owl limpet, Lottia gigantea was also investigated for nuclear receptors. Thirty-nine and thirty-three putative NRs were identified from the B. glabrata and L. gigantea genomes respectively, based on the presence of a conserved DNA-binding domain and/or ligand-binding domain. Nuclear receptor transcript expression was confirmed and sequences were subjected to a comparative phylogenetic analysis, which demonstrated that these molluscs have representatives of all the major NR subfamilies (1-6). Many of the identified NRs are conserved between vertebrates and invertebrates, however differences exist, most notably, the absence of receptors of Group 3C, which includes some of the vertebrate endocrine hormone targets. The mollusc genomes also contain NR homologues that are present in insects and nematodes but not in vertebrates, such as Group 1J (HR48/DAF12/HR96). The identification of many shared receptors between humans and molluscs indicates the potential for molluscs as model organisms; however the absence of several steroid hormone receptors indicates snail endocrine systems are fundamentally different.
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