Evidence map›Paper›PMID 25849358›Full record

Trial reportPloS one2015

Longitudinal neurostimulation in older adults improves working memory.

Kevin T Jones, Jaclyn A Stephens, Mahtab Alam, Marom Bikson, Marian E Berryhill

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  17. Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2017
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kevin T JonesMemory and Brain Laboratory, Department of Psychology, University of Nevada, Reno, Nevada, United States of America; Cognitive Neuropsychology Lab, Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Jaclyn A StephensMemory and Brain Laboratory, Department of Psychology, University of Nevada, Reno, Nevada, United States of America.
Mahtab AlamDepartment of Biomedical Engineering, The City College of New York, New York, New York, United States of America.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York, New York, New York, United States of America.
Marian E BerryhillMemory and Brain Laboratory, Department of Psychology, University of Nevada, Reno, Nevada, United States of America.

Funding

Virtual Reality and Augmented Reality CoreP20GM103650 · NIGMS · UNIVERSITY OF NEVADA RENO · PI WEBSTER, MICHAEL A · 2012 to 2022
$20.9M
Investigating Working Memory Encoding using Frequency-Tagging of Evoked ResponseR15EY022775 · NEI · UNIVERSITY OF NEVADA RENO · PI BERRYHILL, MARIAN E, CAPLOVITZ, GIDEON PAUL · 2012 to 2012
$407k
NEI NIH HHS R15 EY022775NEI NIH HHS R15EY022775NIGMS NIH HHS 1P20GM103650NIGMS NIH HHS P20 GM103650
6 · The paper itself

Abstract

An increasing concern affecting a growing aging population is working memory (WM) decline. Consequently, there is great interest in improving or stabilizing WM, which drives expanded use of brain training exercises. Such regimens generally result in temporary WM benefits to the trained tasks but minimal transfer of benefit to untrained tasks. Pairing training with neurostimulation may stabilize or improve WM performance by enhancing plasticity and strengthening WM-related cortical networks. We tested this possibility in healthy older adults. Participants received 10 sessions of sham (control) or active (anodal, 1.5 mA) tDCS to the right prefrontal, parietal, or prefrontal/parietal (alternating) cortices. After ten minutes of sham or active tDCS, participants performed verbal and visual WM training tasks. On the first, tenth, and follow-up sessions, participants performed transfer WM tasks including the spatial 2-back, Stroop, and digit span tasks. The results demonstrated that all groups benefited from WM training, as expected. However, at follow-up 1-month after training ended, only the participants in the active tDCS groups maintained significant improvement. Importantly, this pattern was observed for both trained and transfer tasks. These results demonstrate that tDCS-linked WM training can provide long-term benefits in maintaining cognitive training benefits and extending them to untrained tasks.

Indexed as

Memory, Short-TermAdultAgedCerebral CortexFemaleFollow-Up StudiesHumansMaleMemory DisordersMiddle AgedNerve Net

Identifiers

PMID25849358
PMCPMC4388845

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.