ArticlePloS one2015
Induction of size-dependent breakdown of blood-milk barrier in lactating mice by TiO2 nanoparticles.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Maternal exposure to titanium dioxide nanoparticles disrupts ultrasonic vocalization development in mouse offspring.Particle and fibre toxicology · 2026Article
- The Dual Role of Nanomaterials in Ovarian Cancer and Female Fertility as Anti- and Prooxidants.Antioxidants (Basel, Switzerland) · 2025Review
- Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multigenerational inheritance of breathing deficits following perinatal exposure to titanium dioxide nanoparticles in the offspring of mice.Discover nano · 2024Article
- GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.International journal of biological sciences · 2021Article
- Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation.Nature food · 2020Article
- Targeting gut microbiota as a possible therapy for mastitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Preventative Effects of Vitamin E on Testicular Damage and Sperm Parameters in the First-Generation Mice Pups due to Pre- and Postnatal Mancozeb Exposure.Journal of toxicology · 2019Article
- Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma.International journal of oncology · 2018Article
- Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide.British journal of pharmacology · 2017Article
- Propionate Protects against Lipopolysaccharide-Induced Mastitis in Mice by Restoring Blood-Milk Barrier Disruption and Suppressing Inflammatory Response.Frontiers in immunology · 2017Article
- Effect of bisphenol A on morphology, apoptosis and proliferation in the resting mammary gland of the adult albino rat.International journal of experimental pathology · 2016Article
- Safety Profile of TiO₂-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the potential nanotoxic effects of TiO2 nanoparticles (TNPs) to dams and pups during lactation period. TiO2 nanoparticles are accumulated in mammary glands of lactating mice after i.v. administration. This accumulation of TiO2 NP likely causes a ROS-induced disruption of tight junction of the blood-milk barrier as indicated by the loss of tight junction proteins and the shedding of alveolar epithelial cells. Compared to larger TNPs (50 nm), smaller ones (8 nm) exhibit a higher accumulation in mammary glands and are more potent in causing perturbations to blood-milk barrier. An alarming finding is that the smaller TNPs (8 nm) are transferred from dams to pups through breastfeeding, likely through the disrupted blood-milk barrier. However, during the lactation period, the nutrient quality of milk from dams and the early developmental landmarks of the pups are not affected by above perturbations.
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Registered trials
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