ArticlePloS one2015
Catecholamines promote Actinobacillus pleuropneumoniae growth by regulating iron metabolism.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Sympathetic denervation alters pulmonary microbiota diversity and composition in mice.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Immunomodulatory effect of stress hormones on porcine neutrophil functions during Actinobacillus pleuropneumoniae infection.Medical microbiology and immunology · 2026Article
- Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026Article
- Forging biofilms: metal-induced microbial responses in biofilm formation.Journal of bacteriology · 2025Review
- Genome analysis reveals diverse novel psychrotolerantISME communications · 2025Article
- The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model.Acta biochimica et biophysica Sinica · 2024Article
- Dopamine promotesFrontiers in cellular and infection microbiology · 2024Article
- Involvement of theFrontiers in veterinary science · 2022Article
- Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology.Frontiers in microbiology · 2021Review
- Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infection.Scientific reports · 2020Article
- Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103.Scientific reports · 2019Article
- The stress hormone norepinephrine increases the growth and virulence of Aeromonas hydrophila.MicrobiologyOpen · 2019Article
- Constitutive expression of antimicrobial peptide PR-39 in transgenic mice significantly enhances resistance to bacterial infection and promotes growth.Transgenic research · 2018Article
- QseBC, a two-component bacterial adrenergic receptor and global regulator of virulence in Enterobacteriaceae and Pasteurellaceae.Molecular oral microbiology · 2016Review
- Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.Infection and immunity · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catecholamines are host stress hormones that can induce the growth of many bacteria by facilitating iron utilization and/or regulate the expression of virulence genes through specific hormone receptors. Whether these two responsive pathways are interconnected is unknown. In our previous study, it was found that catecholamines can regulate the expression of a great number of genes of Actinobacillus pleuropneumoniae, an important swine respiratory pathogen. However, bacterial growth was not affected by catecholamines in rich medium. In this study, it was discovered that catecholamines affected A. pleuropneumoniae growth in chemically defined medium (CDM). We found that serum inhibited A. pleuropneumoniae growth in CDM, while epinephrine, norepinephrine and dopamine promoted A. pleuropneumoniae growth in the CDM containing serum. The known bacterial hormone receptor QseC didn't play roles in this process. Ion-supplementation and transcriptome analysis indicated that serum addition resulted in iron-restricted conditions which were alleviated by the addition of catecholamines. Transferrin, one of the components in serum, inhibited the growth of A. pleuropneumoniae in CDM, an effect reversed by addition of catecholamines in a TonB2-dependent manner. Our data demonstrate that catecholamines promote A. pleuropneumoniae growth by regulating iron-acquisition and metabolism, which is independent of the adrenergic receptor QseC.
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