ReviewNature reviews. Neurology2015
Stimulation mapping of white matter tracts to study brain functional connectivity.
Review in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 163 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anatomo-functional Study of the Brain Cortical and Sub-cortical Connectivity Using Diffusion MRI, Electrocorticography and Direct Electrical Stimulation
Prospective Study of Awake Intraoperative Language Mapping and Construction of Chinese Probabilistic Map Based on Direct Electrical Stimulation
Multimodal Connectome Study of Brain Tumor-operated Patients
Neuroimaging Study on the Recombination of Brain Motor and Language Function Induced by Glioma
Who cites it
163 citing papers in PubMed, 4 syntheses or guidelines pooled it, 414 citations in OpenAlex.
- Connectome-guided glioma resection: a systematic review of white matter tract preservation and postoperative neurocognition.Neurosurgical review · 2026Pooled it
- Neural bases of the bodily self as revealed by electrical brain stimulation: A systematic review.Human brain mapping · 2023Pooled it
- Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review.Neurosurgical review · 2021Pooled it
- A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping.Neuroradiology · 2017Pooled it
- A systematic review of the impact of stimulus presentation modality on fMRI studies for presurgical mapping.Neuroimage. Reports · 2026Review
- Structural and functional anatomy of the superior longitudinal fasciculus: a historical and contemporary narrative review.Anatomical science international · 2026Review
- Addressing connectomic constraints in early practice of awake-guided neurosurgery: a four-year prospective case-matched analysis.Acta neurochirurgica · 2026Article
- Intraoperative technological advances and new frontiers in precision glioma surgery.Journal of neuro-oncology · 2026Review
- Supramaximal resection in gliomas: a narrative review of surgical techniques, clinical outcomes, and ethical considerations.Annals of medicine and surgery (2012) · 2026Review
- Stage-Dependent Physiotherapy for Recovery From Supplementary Motor Area Syndrome: A Case Report.Brain & NeuroRehabilitation · 2026Article
- Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol.Journal of neuro-oncology · 2026Review
- The anatomical and radiologic relationship of the superior longitudinal system with the middle cerebral artery branches.Acta neurochirurgica · 2026Article
- Unlocking the mind: brain mapping for the exploratory quest of functional and cognitive networks in awake neurosurgery.Neurosurgical review · 2026Article
- Moderating role of executive function in the relationship between specific white matter changes and long-term delayed recall in aMCI patients.Alzheimer's research & therapy · 2026Article
- Neuroradiological Insights into Visual Mental Imagery: Structural and Functional Imaging of Ventral and Dorsal Streams.Brain sciences · 2026Review
- Mapping white matter tracts with SEEG electrodes.Epilepsia · 2026Article
- Traveling large distances for awake functional-based surgery of IDH-mutated grade 2 glioma: outcomes comparison between loco-regional versus international patients.Journal of neuro-oncology · 2026Article
- Digital Twin Model of Treatment Outcomes in Post-Stroke Aphasia.medRxiv : the preprint server for health sciences · 2026Article
- Tractometry-Based Quantification of Along-Tract White-Matter Hemispheric Asymmetry in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- The future of neurosurgical oncology lies in cognitive neurosciences: understanding brain processing is much more valuable than surgical technology.Frontiers in oncology · 2026Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite advances in the new science of connectomics, which aims to comprehensively map neural connections at both structural and functional levels, techniques to directly study the function of white matter tracts in vivo in humans have proved elusive. Direct electrical stimulation (DES) mapping of the subcortical fibres offers a unique opportunity to investigate the functional connectivity of the brain. This original method permits real-time anatomo-functional correlations, especially with regard to neural pathways, in awake patients undergoing brain surgery. In this article, the goal is to review new insights, gained from axonal DES, into the functional connectivity underlying the sensorimotor, visuospatial, language and sociocognitive systems. Interactions between these neural networks and multimodal systems, such as working memory, attention, executive functions and consciousness, can also be investigated by axonal stimulation. In this networking model of conation and cognition, brain processing is not conceived as the sum of several subfunctions, but results from the integration and potentiation of parallel-though partially overlapping-subnetworks. This hodotopical account, supported by axonal DES, improves our understanding of neuroplasticity and its limitations. The clinical implications of this paradigmatic shift from localizationism to hodotopy, in the context of brain surgery, neurology, neurorehabilitation and psychiatry, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.