Trial reportMedical science monitor : international medical journal of experimental and clinical research2015
Antioxidant vitamin C prevents decline in endothelial function during sitting.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Diet and ideal food pyramid to prevent or support the treatment of diabetic retinopathy, age-related macular degeneration, and cataracts.Frontiers in medicine · 2023Pooled it
- The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Vascular Function Among Adults: A Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Pooled it
- Dietary flavanols preserve upper- and lower-limb endothelial function during sitting in high- and low-fit young healthy males.The Journal of physiology · 2026Trial
- Leg fidgeting alleviates reduced oxygen extraction in the gastrocnemius muscle caused by prolonged sitting: a randomized crossover trial.European journal of applied physiology · 2025Trial
- Effect of different walking break strategies on superficial femoral artery endothelial function.Physiological reports · 2019Trial
- Effects of prior aerobic exercise on sitting-induced vascular dysfunction in healthy men.European journal of applied physiology · 2017Trial
- The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure.Nutrition journal · 2017Trial
- The impact of a 12-week high-intensity interval training program on popliteal vascular responses to prolonged sitting.European journal of applied physiology · 2026Article
- Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.Physiological reports · 2025Article
- Sitting leg vasculopathy: potential adaptations beyond the endothelium.American journal of physiology. Heart and circulatory physiology · 2024Review
- How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?Nutrients · 2023Review
- Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases.Medicina (Kaunas, Lithuania) · 2023Review
- A Mediterranean Diet May Be Protective in the Development of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy-A Review of the Literature.Nutrients · 2022Review
- Cardiovasomobility: an integrative understanding of how disuse impacts cardiovascular and skeletal muscle health.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Review
- Detrimental effects of physical inactivity on peripheral and brain vasculature in humans: Insights into mechanisms, long-term health consequences and protective strategies.Frontiers in physiology · 2022Review
- Sit less and move more for cardiovascular health: emerging insights and opportunities.Nature reviews. Cardiology · 2021Review
- Vitamin C Acutely Affects Brain Perfusion and Mastication-Induced Perfusion Asymmetry in the Principal Trigeminal Nucleus.Frontiers in systems neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting. MATERIAL AND
methodsEleven men (24.2 ± 4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h.
resultsBy a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05).
conclusionsThree hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.