ArticleThe ISME journal2015
Growth phase-specific evolutionary benefits of natural transformation in Acinetobacter baylyi.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Targeting Horizontal Gene Transfer to Combat Antimicrobial Resistance: A Review of Mechanisms, Drivers, and Multi-Omics Strategies.Infection and drug resistance · 2026Review
- Surviving the storm: exploring the role of natural transformation in nutrition and DNA repair of stressedApplied and environmental microbiology · 2025Article
- Naturally competent bacteria and their genetic parasites-a battle for control over horizontal gene transfer?FEMS microbiology reviews · 2025Review
- Natural transformation-specific DprA coordinate DNA double-strand break repair pathways in heavily irradiatedApplied and environmental microbiology · 2024Article
- Effect of chemotherapeutic agents on natural transformation frequency in Acinetobacter baylyi.Access microbiology · 2024Article
- Testing for the fitness benefits of natural transformation during community-embedded evolution.Microbiology (Reading, England) · 2023Article
- Distribution of fitness effects of cross-species transformation reveals potential for fast adaptive evolution.The ISME journal · 2023Article
- Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation.ISME communications · 2022Article
- Recombination resolves the cost of horizontal gene transfer in experimental populations ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation.The ISME journal · 2022Article
- Antimicrobial Resistance in Nosocomial Isolates of Gram-Negative Bacteria: Public Health Implications in the Latvian Context.Antibiotics (Basel, Switzerland) · 2021Article
- Adaptive evolution of hybrid bacteria by horizontal gene transfer.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- New Provisional Function of OmpA frommSystems · 2021Article
- Effect of Nutritional Determinants and TonB on the Natural Transformation ofFrontiers in microbiology · 2021Article
- Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Non-antibiotic pharmaceuticals enhance the transmission of exogenous antibiotic resistance genes through bacterial transformation.The ISME journal · 2020Article
- Review
- Costs and benefits of natural transformation in Acinetobacter baylyi.BMC microbiology · 2017Article
- No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system.Scientific reports · 2016Article
- Steady at the wheel: conservative sex and the benefits of bacterial transformation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural transformation in bacteria facilitates the uptake and genomic integration of exogenous DNA. This allows horizontal exchange of adaptive traits not easily achieved by point mutations, and has a major role in the acquisition of adaptive traits exemplified by antibiotic resistance determinants and vaccination escape. Mechanisms of DNA uptake and genomic integration are well described for several naturally transformable bacterial species; however, the selective forces responsible for its evolution and maintenance are still controversial. In this study we evolved transformation-proficient and -deficient Acinetobacter baylyi for 175 days in serial transfer cultures where stress was included. We found that natural transformation-proficient populations adapted better to active growth and early stationary phase. This advantage was offset by the reduced performance in the late stationary/death phase. We demonstrate fitness trade-offs between adaptation to active growth and survival in stationary/death phase caused by antagonistic pleiotropy. The presented data suggest that the widely held assumption that recombination speeds up adaptation by rapid accumulation of multiple adaptive mutations in the same genetic background is not sufficient to fully account for the maintenance of natural transformation in bacteria.
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