ArticleNature immunology2015
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
Article in Nature immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 37 citations in OpenAlex.
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- Suicidality as a potential risk and therapeutic target during widespread GLP-1 receptor agonists use: implications of inflammation.Frontiers in synaptic neuroscience · 2026Article
- A crosstalk between the immune system and obstructive sleep apnea.Frontiers in immunology · 2026Review
- Hypothalamic Menin regulates systemic aging and cognitive decline.PLoS biology · 2023Article
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- Ketogenic diet uncovers differential metabolic plasticity of brain cells.Science advances · 2022Article
- Hypothalamic administration of sargahydroquinoic acid elevates peripheral thermogenic signaling and ameliorates high fat diet-induced obesity through the sympathetic nervous system.Scientific reports · 2021Article
- Neural Mechanisms of Cancer Cachexia.Cancers · 2021Review
- Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine.Frontiers in molecular neuroscience · 2021Article
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- When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic Ossification.Current osteoporosis reports · 2020Review
- Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1.Nature neuroscience · 2020Article
- An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.NPJ Regenerative medicine · 2020Article
- The Sleep-Immune Crosstalk in Health and Disease.Physiological reviews · 2019Review
- An evolutionary perspective on immunometabolism.Science (New York, N.Y.) · 2019Review
- Glia-immune interactions post-ischemic stroke and potential therapies.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation.Cell reports · 2018Article
- Central s-resistin deficiency ameliorates hypothalamic inflammation and increases whole body insulin sensitivity.Scientific reports · 2018Article
- Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.Critical reviews in immunology · 2018Review
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6 authors at 1 institution in 1 country.
Funding
Abstract
Innate immunological signals induced by pathogen- and/or damage-associated molecular patterns are essential for adaptive immune responses, but it is unclear if the brain has a role in this process. Here we found that while the abundance of tumor-necrosis factor (TNF) quickly increased in the brain of mice following bacterial infection, intra-brain delivery of TNF mimicked bacterial infection to rapidly increase the number of peripheral lymphocytes, especially in the spleen and fat. Studies of various mouse models revealed that hypothalamic responses to TNF were accountable for this increase in peripheral lymphocytes in response to bacterial infection. Finally, we found that hypothalamic induction of lipolysis mediated the brain's action in promoting this increase in the peripheral adaptive immune response. Thus, the brain-fat axis is important for rapid linkage of innate immunity to adaptive immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.