Trial reportPloS one2015
Self-regulation of brain activity in patients with postherpetic neuralgia: a double-blind randomized study using real-time FMRI neurofeedback.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Neurofeedback for Pain Management: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- A Guide to Literature Informed Decisions in the Design of Real Time fMRI Neurofeedback Studies: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- A systematic review of fMRI neurofeedback reporting and effects in clinical populations.NeuroImage. Clinical · 2020Pooled it
- Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Trial
- Altered Resting-State Amygdala Functional Connectivity after Real-Time fMRI Emotion Self-Regulation Training.BioMed research international · 2016Trial
- Altered Brain Functional Connectivity in Postherpetic Neuralgia and Its Association With Neuropathic Pain.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes.Journal of neurodevelopmental disorders · 2024Article
- Identifying brain targets for real-time fMRI neurofeedback in chronic pain: insights from functional neurosurgery.Psychoradiology · 2024Article
- Evaluating the effectiveness of neurofeedback in chronic pain management: a narrative review.Frontiers in psychology · 2024Review
- Selecting an optimal real-time fMRI neurofeedback method for alcohol craving control training.Psychophysiology · 2023Article
- Neurofeedback-dependent influence of the ventral striatum using a working memory paradigm targeting the dorsolateral prefrontal cortex.Frontiers in behavioral neuroscience · 2023Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- fMRI Brain Decoding and Its Applications in Brain-Computer Interface: A Survey.Brain sciences · 2022Article
- Brain circuits for pain and its treatment.Science translational medicine · 2021Review
- Real-Time Functional Magnetic Resonance Imaging Neurofeedback for the Relief of Distressing Auditory-Verbal Hallucinations: Methodological and Empirical Advances.Schizophrenia bulletin · 2020Review
- Neurofunctional and behavioural measures associated with fMRI-neurofeedback learning in adolescents with Attention-Deficit/Hyperactivity Disorder.NeuroImage. Clinical · 2020Article
- Increased left inferior fronto-striatal activation during error monitoring after fMRI neurofeedback of right inferior frontal cortex in adolescents with attention deficit hyperactivity disorder.NeuroImage. Clinical · 2020Article
- Control freaks: Towards optimal selection of control conditions for fMRI neurofeedback studies.NeuroImage · 2019Article
- When the Brain Takes 'BOLD' Steps: Real-Time fMRI Neurofeedback Can Further Enhance the Ability to Gradually Self-regulate Regional Brain Activation.Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA pilot study has shown that real-time fMRI (rtfMRI) neurofeedback could be an alternative approach for chronic pain treatment. Considering the relative small sample of patients recruited and not strictly controlled condition, it is desirable to perform a replication as well as a double-blinded randomized study with a different control condition in chronic pain patients. Here we conducted a rtfMRI neurofeedback study in a subgroup of pain patients - patients with postherpetic neuralgia (PHN) and used a different sham neurofeedback control. We explored the feasibility of self-regulation of the rostral anterior cingulate cortex (rACC) activation in patients with PHN through rtfMRI neurofeedback and regulation of pain perception.
methodsSixteen patients (46-71 years) with PHN were randomly allocated to a experimental group (n = 8) or a control group (n = 8). 2 patients in the control group were excluded for large head motion. The experimental group was given true feedback information from their rACC whereas the control group was given sham feedback information from their posterior cingulate cortex (PCC). All subjects were instructed to perform an imagery task to increase and decrease activation within the target region using rtfMRI neurofeedback.
resultsOnline analysis showed 6/8 patients in the experimental group were able to increase and decrease the blood oxygen level dependent (BOLD) fMRI signal magnitude during intermittent feedback training. However, this modulation effect was not observed in the control group. Offline analysis showed that the percentage of BOLD signal change of the target region between the last and first training in the experimental group was significantly different from the control group's and was also significantly different than 0. The changes of pain perception reflected by numerical rating scale (NRS) in the experimental group were significantly different from the control group. However, there existed no significant correlations between BOLD signal change and NRS change.
conclusionPatients with PHN could learn to voluntarily control over activation in rACC through rtfMRI neurofeedback and alter their pain perception level. The present study may provide new evidence that rtfMRI neurofeedback training may be a supplemental approach for chronic clinical pain management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.